ArticlePloS one2013
Gas2l3, a novel constriction site-associated protein whose regulation is mediated by the APC/C Cdh1 complex.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- IDR-driven LLPS of GAS2L3 scaffolds CHMP4B condensates to accelerate cytokinesis in hepatocellular carcinoma cells.Journal of advanced research · 2026Article
- Cytokinetic abscission requires actin-dependent microtubule severing.Nature communications · 2024Article
- Affinity microfluidics enables high-throughput protein degradation analysis in cell-free extracts.Communications biology · 2022Article
- Integrative analysis regarding the correlation between GAS2 family genes and human glioma prognosis.Cancer medicine · 2021Article
- Growth arrest-specific 2 protein family: Structure and function.Cell proliferation · 2021Review
- Elevated GAS2L3 Expression Correlates With Poor Prognosis in Patients With Glioma: A Study Based on Bioinformatics and Immunohistochemical Analysis.Frontiers in genetics · 2021Article
- Article
- Cell cycle oscillators underlying orderly proteolysis of E2F8.Molecular biology of the cell · 2020Article
- GAS2-like 1 coordinates cell division through its association with end-binding proteins.Scientific reports · 2019Article
- GAS2L3: Coordinator of cardiomyocyte cytokinesis?Cell cycle (Georgetown, Tex.) · 2017Article
- Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The Gas2 family protein Pigs is a microtubule +TIP that affects cytoskeleton organisation.Journal of cell science · 2016Article
- Integrated Microfluidics for Protein Modification Discovery.Molecular & cellular proteomics : MCP · 2015Article
- Purifying Cytokinetic Cells from an Asynchronous Population.Scientific reports · 2015Article
- Co-regulation proteomics reveals substrates and mechanisms of APC/C-dependent degradation.The EMBO journal · 2014Article
- Cytokinetic abscission is an acute G1 event.Cell cycle (Georgetown, Tex.) · 2014Article
- Review
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Authors and funding
10 authors.
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Abstract
Growth arrest-specific 2-like protein 3 (Gas2l3) was recently identified as an Actin/Tubulin cross-linker protein that regulates cytokinesis. Using cell-free systems from both frog eggs and human cells, we show that the Gas2l3 protein is targeted for ubiquitin-mediated proteolysis by the APC/C(Cdh1) complex, but not by the APC/C(Cdc20) complex, and is phosphorylated by Cdk1 in mitosis. Moreover, late in cytokinesis, Gas2l3 is exclusively localized to the constriction sites, which are the narrowest parts of the intercellular bridge connecting the two daughter cells. Overexpression of Gas2l3 specifically interferes with cell abscission, which is the final stage of cell division, when the cutting of the intercellular bridge at the constriction sites occurs. We therefore suggest that Gas2l3 is part of the cellular mechanism that terminates cell division.
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