ArticlePloS one2013
Gene knockout study reveals that cytosolic ascorbate peroxidase 2(OsAPX2) plays a critical role in growth and reproduction in rice under drought, salt and cold stresses.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.
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103 citing papers in PubMed, 256 citations in OpenAlex.
- Integrative RNA sequencing uncovers the miRNA-mRNA landscape of water-deficit response in Setaria italica.Planta · 2026Article
- Overexpression of PagAPX8 promotes poplar growth and enhances tolerance to drought and salt stress.Plant cell reports · 2026Article
- Conserved 4-coumarate 3-hydroxylase/ascorbate peroxidase bifunctionality coordinates lignin deposition and plant growth in Brachypodium and Populus.Plant physiology · 2026Article
- Comparative analysis of salt tolerance and associated physiological traits in wild and cultivated barley at the seedling stage.BMC plant biology · 2026Article
- Physiological traits and related gene expression of salt tolerance in hybrid rice Jingliangyou 3261 at the seedling stage.BMC plant biology · 2026Article
- OsFeSOD3 Functions as an Enzymatic Component of the PEP Complex, Bifunctionally Regulating Chloroplastic ROS Metabolism and Chloroplast Biogenesis in Rice.Plant biotechnology journal · 2026Article
- Genome-Wide Identification and Functional Studies of the APX Gene Family in Oat (Life (Basel, Switzerland) · 2026Article
- OsSSID6 Negatively Regulates Salt Stress Tolerance in Rice (Oryza Sativa L.) via Metabolic Pathways and ROS Scavenging.Rice (New York, N.Y.) · 2025Article
- Different Substrates Drive Differential Responses of Rice to Salt Stress.Rice (New York, N.Y.) · 2025Article
- Integrative Physiological, Metabolomic and Transcriptomic Analyses Uncover the Mechanisms Underlying Differential Responses of TwoBiomolecules · 2025Article
- Chromosome-level genome of Zoysia sinica in the intertidal zone reveals genomic insights into waterlogging stress adaptation.The plant genome · 2025Article
- Natural Variation of PH8 Allele Improves Architecture and Cold Tolerance in Rice.Rice (New York, N.Y.) · 2025Article
- Lesion Mimic Mutant: An Ideal Genetic Material for Deciphering the Balance Between Plant Immunity and Growth.Rice (New York, N.Y.) · 2025Review
- Heterologous expression of physic nut JcHDZ25 confers tolerance to drought stress in transgenic rice.BMC genomics · 2025Article
- E3 Ubiquitin Ligase OsRFI2 Regulates Salinity Tolerance by Targeting Ascorbate Peroxidase OsAPX8 for its Degradation in Rice.Rice (New York, N.Y.) · 2025Article
- Evaluating Physiological and Hormonal Responses of Two Distinct Rice Genotypes Under High Temperatures.Plants (Basel, Switzerland) · 2025Article
- MIKC-type MADS-box transcription factor OsMADS31 positively regulates salinity tolerance in rice.Frontiers in plant science · 2025Article
- Evaluation and genome-wide association study of saline-alkali tolerance in high-latitude rice resource populations.Frontiers in genetics · 2025Article
- Decoding the role of durum wheat ascorbate peroxidase TdAPX7B-2 in abiotic stress response.Functional & integrative genomics · 2024Article
- Identification of the new allele ptc1-2 and analysis of the regulatory role of PTC1 gene in rice anther development.BMC plant biology · 2024Article
43 more citing papers are in PubMed but not listed here.
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8 authors at 3 institutions in 1 country.
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Abstract
Plant ascorbate peroxidases (APXs), enzymes catalyzing the dismutation of H2O2 into H2O and O2, play an important role in reactive oxygen species homeostasis in plants. The rice genome has eight OsAPXs, but their physiological functions remain to be determined. In this report, we studied the function of OsAPX2 gene using a T-DNA knockout mutant under the treatment of drought, salt and cold stresses. The Osapx2 knockout mutant was isolated by a genetic screening of a rice T-DNA insertion library under 20% PEG-2000 treatment. Loss of function in OsAPX2 affected the growth and development of rice seedlings, resulting in semi-dwarf seedlings, yellow-green leaves, leaf lesion mimic and seed sterility. OsAPX2 expression was developmental- and spatial-regulated, and was induced by drought, salt, and cold stresses. Osapx2 mutants had lower APX activity and were sensitive to abiotic stresses; overexpression of OsAPX2 increased APX activity and enhanced stress tolerance. H2O2 and MDA levels were high in Osapx2 mutants but low in OsAPX2-OX transgenic lines relative to wild-type plants after stress treatments. Taken together, the cytosolic ascorbate peroxidase OsAPX2 plays an important role in rice growth and development by protecting the seedlings from abiotic stresses through scavenging reactive oxygen species.
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