ArticlePloS one2013
Mef2c regulates transcription of the extracellular matrix protein cartilage link protein 1 in the developing murine heart.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- MEF2C Directly Interacts with Pre-miRNAs and Distinct RNPs to Post-Transcriptionally Regulate miR-23a-miR-27a-miR-24-2 microRNA Cluster Member Expression.Non-coding RNA · 2024Article
- Differential requirement for DICER1 activity during the development of mitral and tricuspid valves.Journal of cell science · 2022Article
- Transcriptome Dynamics in the Developing Larynx, Trachea, and Esophagus.Frontiers in cell and developmental biology · 2022Article
- Comparative transcriptomic profiling of myxomatous mitral valve disease in the cavalier King Charles spaniel.BMC veterinary research · 2020Article
- Circulating plasma circular RNAs as novel diagnostic biomarkers for congenital heart disease in children.Journal of clinical laboratory analysis · 2019Article
- Analysis of a limb-specific regulatory element in the promoter of the link protein gene.Biochemical and biophysical research communications · 2019Article
- Zebrafish Vestigial Like Family Member 4b Is Required for Valvulogenesis Through Sequestration of Transcription Factor Myocyte Enhancer Factor 2c.Frontiers in cell and developmental biology · 2019Article
- Identification of key genes associated with congenital heart defects in embryos of diabetic mice.Molecular medicine reports · 2018Article
- MiR-448 promotes vascular smooth muscle cell proliferation and migration in through directly targeting MEF2C.Environmental science and pollution research international · 2017Article
- Genetic association analyses highlight biological pathways underlying mitral valve prolapse.Nature genetics · 2015Article
- Patterns of gene expression in the sheep heart during the perinatal period revealed by transcriptomic modeling.Physiological genomics · 2015Article
- Loss of β-catenin promotes chondrogenic differentiation of aortic valve interstitial cells.Arteriosclerosis, thrombosis, and vascular biology · 2014Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Cartilage Link Protein 1 (Crtl1) is an extracellular matrix (ECM) protein that stabilizes the interaction between hyaluronan and versican and is expressed in endocardial and endocardially-derived cells in the developing heart, including cells in the atrioventricular (AV) and outflow tract (OFT) cushions. Previous investigations into the transcriptional regulation of the Crtl1 gene have shown that Sox9 regulates Crtl1 expression in both cartilage and the AV valves. The cardiac transcription factor Mef2c is involved in the regulation of gene expression in cardiac and skeletal muscle cell lineages. In this study we have investigated the potential role of Mef2c in the regulation of ECM production in the endocardial and mesenchymal cell lineages of the developing heart. We demonstrate that the Crtl1 5' flanking region contains two highly conserved Mef2 binding sites and that Mef2c is able to bind to these sites in vivo during cardiovascular development. Additionally, we show that Crtl1 transcription is dependent on Mef2c expression in fetal mitral valve interstitial cells (VICs). Combined, these findings highlight a new role for Mef2c in cardiac development and the regulation of cardiac extracellular matrix protein expression.
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