ArticlePloS one2013
De Novo transcriptome assembly (NGS) of Curcuma longa L. rhizome reveals novel transcripts related to anticancer and antimalarial terpenoids.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 92 citations in OpenAlex.
- A comprehensive review on genomic resources in medicinally and industrially important major spices for future breeding programs: Status, utility and challenges.Current research in food science · 2023Review
- De novo transcriptome assembly, gene annotation, and EST-SSR marker development of an important medicinal and edible crop, Amomum tsaoko (Zingiberaceae).BMC plant biology · 2022Article
- Designing a Novel Functional Peptide With Dual Antimicrobial and Anti-inflammatory ActivitiesFrontiers in immunology · 2022Article
- Genome sequencing of turmeric provides evolutionary insights into its medicinal properties.Communications biology · 2021Article
- Review
- Development of EST-SSR markers based on transcriptome and its validation in ginger (Zingiber officinale Rosc.).PloS one · 2021Article
- The Role of Chromatographic and Electromigration Techniques in Foodomics.Advances in experimental medicine and biology · 2021Article
- Associating gene expressions with curcuminoid biosynthesis in turmeric.Journal, genetic engineering & biotechnology · 2020Article
- De novo assembly and characterization of transcriptome in the medicinal plant Euphorbia jolkini.Genes & genomics · 2020Article
- The GAMYB gene in rye: sequence, polymorphisms, map location, allele-specific markers, and relationship with α-amylase activity.BMC genomics · 2020Article
- Antibacterial and Anti-Inflammatory Effects of Novel Peptide Toxin from the SpiderAntibiotics (Basel, Switzerland) · 2020Article
- Article
- Genetic Divergence and Relationship AmongFrontiers in genetics · 2020Article
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- Transcriptome Sequencing and Development of Novel Genic SSR Markers FromFrontiers in genetics · 2020Article
- Article
- De novo transcriptome of Gymnema sylvestre identified putative lncRNA and genes regulating terpenoid biosynthesis pathway.Scientific reports · 2019Article
- De novo assembly of transcriptomes, mining, and development of novel EST-SSR markers in Curcuma alismatifolia (Zingiberaceae family) through Illumina sequencing.Scientific reports · 2019Article
- Molecular authentication ofSaudi journal of biological sciences · 2019Article
- De novo transcriptome sequencing and metabolite profiling analyses reveal the complex metabolic genes involved in the terpenoid biosynthesis in Blue Anise Sage (Salvia guaranitica L.).DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
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12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Herbal remedies are increasingly being recognised in recent years as alternative medicine for a number of diseases including cancer. Curcuma longa L., commonly known as turmeric is used as a culinary spice in India and in many Asian countries has been attributed to lower incidences of gastrointestinal cancers. Curcumin, a secondary metabolite isolated from the rhizomes of this plant has been shown to have significant anticancer properties, in addition to antimalarial and antioxidant effects. We sequenced the transcriptome of the rhizome of the 3 varieties of Curcuma longa L. using Illumina reversible dye terminator sequencing followed by de novo transcriptome assembly. Multiple databases were used to obtain a comprehensive annotation and the transcripts were functionally classified using GO, KOG and PlantCyc. Special emphasis was given for annotating the secondary metabolite pathways and terpenoid biosynthesis pathways. We report for the first time, the presence of transcripts related to biosynthetic pathways of several anti-cancer compounds like taxol, curcumin, and vinblastine in addition to anti-malarial compounds like artemisinin and acridone alkaloids, emphasizing turmeric's importance as a highly potent phytochemical. Our data not only provides molecular signatures for several terpenoids but also a comprehensive molecular resource for facilitating deeper insights into the transcriptome of C. longa.
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