ArticlePLoS computational biology2013
Analysis of a gene regulatory cascade mediating circadian rhythm in zebrafish.
Article in PLoS computational biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 75 citations in OpenAlex.
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- Avenues of genome editing for color trait improvement in ornamental fishes: current status and future perspectives.Transgenic research · 2025Review
- Sinusoidal regulation reduces circadian period variability.Scientific reports · 2025Article
- Quantifying the link between retinal performance and the optomotor response.Current biology : CB · 2025Article
- Evolution of canonical circadian clock genes underlies unique sleep strategies of marine mammals for secondary aquatic adaptation.PLoS genetics · 2025Article
- The nature and distribution of putative non-functional alleles suggest only two independent events at the origins of Astyanax mexicanus cavefish populations.BMC ecology and evolution · 2024Article
- Onset of circadian rhythmicity in the brain of Atlantic salmon is linked to exogenous feeding.PloS one · 2024Article
- Circadian regulation of developmental synaptogenesis via the hypocretinergic system.Nature communications · 2023Article
- Detection of Zebrafish Retinal Proteins by Infrared Western Blotting.Bio-protocol · 2023Article
- Juvenile zebrafish (Danio rerio) are able to recover from lordosis.Scientific reports · 2022Article
- Photoreception and transcriptomic response to light during early development of a teleost with a life cycle tightly controlled by seasonal changes in photoperiod.PLoS genetics · 2022Article
- Immunity, Infection, and the Zebrafish Clock.Infection and immunity · 2022Review
- Genetic ablation of the Bsx homeodomain transcription factor in zebrafish: Impact on mature pineal gland morphology and circadian behavior.Journal of pineal research · 2022Article
- Article
- Circadian clock protein BMAL1 regulates melanogenesis through MITF in melanoma cells.Pigment cell & melanoma research · 2021Article
- Intercellular coupling between peripheral circadian oscillators by TGF-β signaling.Science advances · 2021Article
- Repeated evolution of circadian clock dysregulation in cavefish populations.PLoS genetics · 2021Article
- Revealing the hidden reality of the mammalian 12-h ultradian rhythms.Cellular and molecular life sciences : CMLS · 2021Review
- Adaptation and convergence in circadian-related genes in Iberian freshwater fish.BMC ecology and evolution · 2021Article
- Contrasting Gene Decay in Subterranean Vertebrates: Insights from Cavefishes and Fossorial Mammals.Molecular biology and evolution · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the study of circadian rhythms, it has been a puzzle how a limited number of circadian clock genes can control diverse aspects of physiology. Here we investigate circadian gene expression genome-wide using larval zebrafish as a model system. We made use of a spatial gene expression atlas to investigate the expression of circadian genes in various tissues and cell types. Comparison of genome-wide circadian gene expression data between zebrafish and mouse revealed a nearly anti-phase relationship and allowed us to detect novel evolutionarily conserved circadian genes in vertebrates. We identified three groups of zebrafish genes with distinct responses to light entrainment: fast light-induced genes, slow light-induced genes, and dark-induced genes. Our computational analysis of the circadian gene regulatory network revealed several transcription factors (TFs) involved in diverse aspects of circadian physiology through transcriptional cascade. Of these, microphthalmia-associated transcription factor a (mitfa), a dark-induced TF, mediates a circadian rhythm of melanin synthesis, which may be involved in zebrafish's adaptation to daily light cycling. Our study describes a systematic method to discover previously unidentified TFs involved in circadian physiology in complex organisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.