ArticlePLoS computational biology2013
Dynamic modeling of cell migration and spreading behaviors on fibronectin coated planar substrates and micropatterned geometries.
Article in PLoS computational biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 4 citations in OpenAlex.
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- On modeling the multiscale mechanobiology of soft tissues: Challenges and progress.Biophysics reviews · 2022Review
- A computational modeling of invadopodia protrusion into an extracellular matrix fiber network.Scientific reports · 2022Article
- Cardiac Cell Patterning on Customized Microelectrode Arrays for Electrophysiological Recordings.Micromachines · 2021Article
- Computational models of migration modes improve our understanding of metastasis.APL bioengineering · 2020Review
- Modulation of Actin Filament Dynamics by Inward Rectifying of Potassium Channel Kir2.1.International journal of molecular sciences · 2020Article
- An Active Biomechanical Model of Cell Adhesion Actuated by Intracellular Tensioning-Taxis.Biophysical journal · 2020Article
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- A quantitative high-resolution computational mechanics cell model for growing and regenerating tissues.Biomechanics and modeling in mechanobiology · 2020Article
- Modeling of Mechanosensing Mechanisms Reveals Distinct Cell Migration Modes to Emerge From Combinations of Substrate Stiffness and Adhesion Receptor-Ligand Affinity.Frontiers in bioengineering and biotechnology · 2020Article
- Ibuprofen inhibited migration of skeletal muscle cells in association with downregulation of p130cas and CrkII expressions.Skeletal muscle · 2019Article
- Interplay Between the Persistent Random Walk and the Contact Inhibition of Locomotion Leads to Collective Cell Behaviors.Bulletin of mathematical biology · 2019Article
- Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth.Cancer research · 2019Article
- A checkpoint-oriented cell cycle simulation model.Cell cycle (Georgetown, Tex.) · 2019Article
- Mechanical and Systems Biology of Cancer.Computational and structural biotechnology journal · 2018Review
- Influence of Micropatterned Grill Lines onFrontiers in cellular and infection microbiology · 2018Article
- Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses.Physics of life reviews · 2017Review
- How can we predict cellular mechanosensation?: Comment on "Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses" by Bo Cheng et al.Physics of life reviews · 2017Article
- Cell migration on material-driven fibronectin microenvironments.Biomaterials science · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An integrative cell migration model incorporating focal adhesion (FA) dynamics, cytoskeleton and nucleus remodeling, actin motor activity, and lamellipodia protrusion is developed for predicting cell spreading and migration behaviors. This work is motivated by two experimental works: (1) cell migration on 2-D substrates under various fibronectin concentrations and (2) cell spreading on 2-D micropatterned geometries. These works suggest (1) cell migration speed takes a maximum at a particular ligand density (∼1140 molecules/µm(2)) and (2) that strong traction forces at the corners of the patterns may exist due to combined effects exerted by actin stress fibers (SFs). The integrative model of this paper successfully reproduced these experimental results and indicates the mechanism of cell migration and spreading. In this paper, the mechanical structure of the cell is modeled as having two elastic membranes: an outer cell membrane and an inner nuclear membrane. The two elastic membranes are connected by SFs, which are extended from focal adhesions on the cortical surface to the nuclear membrane. In addition, the model also includes ventral SFs bridging two focal adhesions on the cell surface. The cell deforms and gains traction as transmembrane integrins distributed over the outer cell membrane bond to ligands on the ECM surface, activate SFs, and form focal adhesions. The relationship between the cell migration speed and fibronectin concentration agrees with existing experimental data for Chinese hamster ovary (CHO) cell migrations on fibronectin coated surfaces. In addition, the integrated model is validated by showing persistent high stress concentrations at sharp geometrically patterned edges. This model will be used as a predictive model to assist in design and data processing of upcoming microfluidic cell migration assays.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.