ArticlePLoS biology2013
Indirect evolution of hybrid lethality due to linkage with selected locus in Mimulus guttatus.
Article in PLoS biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
- Meta-analysis reveals that phenotypic plasticity and divergent selection promote reproductive isolation during incipient speciation.Nature ecology & evolution · 2025Pooled it
- The molecular evolutionary basis of species formation revisited.Trends in genetics : TIG · 2025Review
- Phylogeographic evidence reveals multiple colonization events and a secondary contact zone in the Balkans for the Anthriscus sylvestris complex (Apiaceae).Scientific reports · 2025Article
- Genetic Basis of Reproductive Isolation in Torrey Pine (Evolutionary applications · 2025Article
- The Ecology of Hybrid Incompatibilities.Cold Spring Harbor perspectives in biology · 2024Review
- Fisher's Geometric Model as a Tool to Study Speciation.Cold Spring Harbor perspectives in biology · 2024Review
- Adaptive divergence, historical population dynamics, and simulation of suitable distributions for Picea Meyeri and P. Mongolica at the whole-genome level.BMC plant biology · 2024Article
- Independently evolved pollution resistance in four killifish populations is largely explained by few variants of large effect.Evolutionary applications · 2024Article
- Anthropogenic Change and the Process of Speciation.Cold Spring Harbor perspectives in biology · 2023Review
- Divergent selection and climate adaptation fuel genomic differentiation between sister species of Sphagnum (peat moss).Annals of botany · 2023Article
- Genomics of plant speciation.Plant communications · 2023Review
- The genetic basis of adaptation to copper pollution inFrontiers in genetics · 2023Article
- The strength of reproductive isolating barriers in seed plants: Insights from studies quantifying premating and postmating reproductive barriers over the past 15 years.Evolution; international journal of organic evolution · 2022Article
- Three problems in the genetics of speciation by selection.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genomic changes underlying repeated niche shifts in an adaptive radiation.Evolution; international journal of organic evolution · 2022Article
- Heterosis counteracts hybrid breakdown to forestall speciation by parallel natural selection.Proceedings. Biological sciences · 2022Article
- Adaptive divergence in shoot gravitropism creates hybrid sterility in an Australian wildflower.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Evolution of multiple postzygotic barriers between species of the Mimulus tilingii complex.Evolution; international journal of organic evolution · 2021Article
- The importance of intrinsic postzygotic barriers throughout the speciation process.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most species are superbly and intricately adapted to the environments in which they live. Adaptive evolution by natural selection is the primary force shaping biological diversity. Differences between closely related species in ecologically selected characters such as habitat preference, reproductive timing, courtship behavior, or pollinator attraction may prevent interbreeding in nature, causing reproductive isolation. But does ecological adaptation cause reproductive incompatibilities such as hybrid sterility or lethality? Although several genes causing hybrid incompatibilities have been identified, there is intense debate over whether the genes that contribute to ecological adaptations also cause hybrid incompatibilities. Thirty years ago, a genetic study of local adaptation to copper mine soils in the wildflower Mimulus guttatus identified a locus that appeared to cause copper tolerance and hybrid lethality in crosses to other populations. But do copper tolerance and hybrid lethality have the same molecular genetic basis? Here we show, using high-resolution genome mapping, that copper tolerance and hybrid lethality are not caused by the same gene but are in fact separately controlled by two tightly linked loci. We further show that selection on the copper tolerance locus indirectly caused the hybrid incompatibility allele to go to high frequency in the copper mine population because of hitchhiking. Our results provide a new twist on Darwin's original supposition that hybrid incompatibilities evolve as an incidental by-product of ordinary adaptation to the environment.
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