ArticleMolecular biology of the cell2013
Ca2+ influx and the store-operated Ca2+ entry pathway undergo regulation during mouse oocyte maturation.
Article in Molecular biology of the cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Fertilization, Oocyte Activation, Calcium Release and Epigenetic Remodelling: Lessons From Cancer Models.Frontiers in cell and developmental biology · 2022Article
- Mitochondrial Calcium uniporters are essential for meiotic progression in mouse oocytes by controlling CaCell proliferation · 2021Article
- Modulators of calcium signalling at fertilization.Open biology · 2020Review
- Divalent cation influx and calcium homeostasis in germinal vesicle mouse oocytes.Cell calcium · 2020Article
- CaCold Spring Harbor perspectives in biology · 2019Review
- Follicle-stimulating hormone and luteinizing hormone increase Ca2+ in the granulosa cells of mouse ovarian follicles†.Biology of reproduction · 2019Article
- Remodeling of ER-plasma membrane contact sites but not STIM1 phosphorylation inhibits CaProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Constitutive IPJournal of cell science · 2019Article
- TRPM7 and CaProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Calcium oscillations in fertilized pig oocytes are associated with repetitive interactions between STIM1 and ORAI1.Biology of reproduction · 2018Article
- Ion Channel Function During Oocyte Maturation and Fertilization.Frontiers in cell and developmental biology · 2018Review
- Calcium influx and sperm-evoked calcium responses during oocyte maturation and egg activation.Oncotarget · 2017Review
- Defective sperm head decondensation undermines the success of ICSI in the bovine.Reproduction (Cambridge, England) · 2017Article
- Store-operated CaCell calcium · 2017Article
- TRPM7-like channels are functionally expressed in oocytes and modulate post-fertilization embryo development in mouse.Scientific reports · 2016Article
- Ca(2+) dynamics in oocytes from naturally-aged mice.Scientific reports · 2016Article
- Fine tuning of cytosolic Ca (2+) oscillations.F1000Research · 2016Review
- CaV3.2 T-type channels mediate Ca²⁺ entry during oocyte maturation and following fertilization.Journal of cell science · 2015Article
- Differential role of STIM1 and STIM2 during transient inward (T in) current generation and the maturation process in the Xenopus oocyte.BMC physiology · 2014Article
- Regulation of endoplasmic reticulum Ca(2+) oscillations in mammalian eggs.Journal of cell science · 2013Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
In preparation for fertilization, mammalian oocytes undergo optimization of the mechanisms that regulate calcium homeostasis. Among these changes is the increase in the content of the Ca(2+) stores ([Ca(2+)]ER), a process that requires Ca(2+) influx. Nevertheless, the mechanism(s) that mediates this influx remains obscure, although is known that [Ca(2+)]ER can regulate Ca(2+) influx via store-operated Ca(2+) entry (SOCE). We find that during maturation, as [Ca(2+)]ER increases, Ca(2+) influx decreases. We demonstrate that mouse oocytes/eggs express the two molecular components of SOCE--stromal interaction molecule 1 (Stim1) and Orai1--and expression of human (h) Stim1 increases Ca(2+) influx in a manner that recapitulates endogenous SOCE. We observe that the cellular distribution of hStim1 and hOrai1 during maturation undergoes sweeping changes that curtail their colocalization during the later stages of maturation. Coexpression of hStim1 and hOrai1 enhances influx throughout maturation but increases basal Ca(2+) levels only in GV oocytes. Further, expression of a constitutive active form of hStim1 plus Orai1, which increases basal Ca(2+) throughout maturation, disturbs resumption of meiosis. Taken together, our results demonstrate that Ca(2+) influx and SOCE are regulated during maturation and that alteration of Ca(2+) homeostasis undermines maturation in mouse oocytes.
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