ArticleJournal of neurophysiology2013
Effects of treadmill training on functional recovery following peripheral nerve injury in rats.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 66 citations in OpenAlex.
- A myoneural actuator with engineered biophysics for implantable biohybrid systems.Nature communications · 2026Article
- Improving nerve and muscle function: an exploration of targeted nerve function replacement following differential delay periods in a rat model.Journal of neuroengineering and rehabilitation · 2025Article
- Effect of Combining Exercise with Adipose-Derived Mesenchymal Stem Cells in Muscle Atrophy Model of Sarcopenia.International journal of molecular sciences · 2025Article
- Modern Medical Rehabilitation Methods for Patients with Peripheral Nerve and Brachial Plexus Injuries (Review).Sovremennye tekhnologii v meditsine · 2025Review
- Water-circulating probes significantly modify lesion length and axon damage in cooled radiofrequency ablations when compared with similar-sized standard radiofrequency probes in rats.Regional anesthesia and pain medicine · 2024Article
- Early Intensive Neurorehabilitation in Traumatic Peripheral Nerve Injury-State of the Art.Animals : an open access journal from MDPI · 2024Review
- The Role of Physical Exercise and Rehabilitative Implications in the Process of Nerve Repair in Peripheral Neuropathies: A Systematic Review.Diagnostics (Basel, Switzerland) · 2023Review
- Hindlimb muscle spindles inform preparatory forelimb coordination prior to landing in toads.The Journal of experimental biology · 2023Article
- Enhancing Motor and Sensory Axon Regeneration after Peripheral Nerve Injury Using Bioluminescent Optogenetics.International journal of molecular sciences · 2022Article
- An electroencephalography-based human-machine interface combined with contralateral C7 transfer in the treatment of brachial plexus injury.Neural regeneration research · 2022Review
- Exercise facilitates regeneration after severe nerve transection and further modulates neural plasticity.Brain, behavior, & immunity - health · 2022Article
- Early Intervention of Cold-Water Swimming on Functional Recovery and Spinal Pain Modulation Following Brachial Plexus Avulsion in Rats.International journal of molecular sciences · 2022Article
- Treadmill training of rats after sciatic nerve graft does not alter accuracy of muscle reinnervation.Frontiers in neurology · 2022Article
- Effect of treadmill exercise combined with bone marrow stromal cell transplantation on atrophy-related signaling pathway in the denervated soleus muscle.Journal of exercise rehabilitation · 2021Article
- The role of exercise on peripheral nerve regeneration: from animal model to clinical application.Heliyon · 2021Review
- Physiological and functional responses of water-cooled versus traditional radiofrequency ablation of peripheral nerves in rats.Regional anesthesia and pain medicine · 2020Article
- Article
- Motoneuron activity is required for enhancements in functional recovery after peripheral nerve injury in exercised female mice.Journal of neuroscience research · 2020Article
- Effects of Repeated 20-Hz Electrical Stimulation on Functional Recovery Following Peripheral Nerve Injury.Neurorehabilitation and neural repair · 2019Article
- Dysregulation of mechanosensory circuits coordinating the actions of antagonist motor pools following peripheral nerve injury and muscle reinnervation.Experimental neurology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Exercise, in the form of moderate daily treadmill training following nerve transection and repair leads to enhanced axon regeneration, but its effect on functional recovery is less well known. Female rats were exercised by walking continuously, at a slow speed (10 m/min), for 1 h/day on a level treadmill, beginning 3 days after unilateral transection and surgical repair of the sciatic nerve, and conducted 5 days/wk for 2 wk. In Trained rats, both direct muscle responses to tibial nerve stimulation and H reflexes in soleus reappeared earlier and increased in amplitude more rapidly over time than in Untrained rats. The efficacy of the restored H reflex was greater in Trained rats than in Untrained controls. The reinnervated tibialis anterior and soleus were coactivated during treadmill locomotion in Untrained rats. In Trained animals, the pattern of activation of soleus, but not tibialis anterior, was not significantly different from that found in Intact rats. The overall length of the hindlimb during level and up- and downslope locomotion was conserved after nerve injury in both groups. This conservation was achieved by changes in limb orientation. Limb length was conserved effectively in all rats during downslope walking but only in Trained rats during level and upslope walking. Moderate daily exercise applied immediately after sciatic nerve transection is sufficient to promote axon regeneration, to restore muscle reflexes, and to improve the ability of rats to cope with different biomechanical demands of slope walking.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.