ReviewThe American journal of tropical medicine and hygiene2013
Impact, challenges, and future projections of vaccine trials in Africa.
Review in The American journal of tropical medicine and hygiene, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Pooled it
- Engagement of the community, traditional leaders, and public health system in the design and implementation of a large community-based, cluster-randomized trial of umbilical cord care in Zambia.The American journal of tropical medicine and hygiene · 2015Trial
- Gaps in vaccine clinical trials in Africa: A mixed scoping review and bibliometric analysis before, during, and post- COVID-19 pandemic.Human vaccines & immunotherapeutics · 2025Article
- Strategies to build trust in the conduct of clinical trials: Stakeholders' views in a qualitative study in Ghana.PLOS global public health · 2025Article
- Defining clinical trial quality from the perspective of resource-limited settings: A qualitative study based on interviews with investigators, sponsors, and monitors conducting clinical trials in sub-Saharan Africa.PLoS neglected tropical diseases · 2022Article
- Conducting clinical research in a resource-constrained setting: lessons from a longitudinal cohort study in The Gambia.BMJ global health · 2021Article
- A review of the safety of vaccines used in routine immunization in Africa.African health sciences · 2020Review
- A systematic scorecard-based approach to site assessment in preparation for Lassa fever vaccine clinical trials in affected countries.Pilot and feasibility studies · 2020Article
- Clinical Protocol for a Longitudinal Cohort Study Employing Systems Biology to Identify Markers of Vaccine Immunogenicity in Newborn Infants in The Gambia and Papua New Guinea.Frontiers in pediatrics · 2020Article
- Article
- Characteristics of funding of clinical trials: cross-sectional survey and proposed guidance.BMJ open · 2017Article
- "You can save time if…"-A qualitative study on internal factors slowing down clinical trials in Sub-Saharan Africa.PloS one · 2017Article
- Increasing protocol suitability for clinical trials in sub-Saharan Africa: a mixed methods study.Global health research and policy · 2017Article
- Clinical Research in Neglected Tropical Diseases: The Challenge of Implementing Good Clinical (Laboratory) Practices.PLoS neglected tropical diseases · 2016Article
- It is time to revise the international Good Clinical Practices guidelines: recommendations from non-commercial North-South collaborative trials.BMJ global health · 2016Article
- Sponsorship in non-commercial clinical trials: definitions, challenges and the role of Good Clinical Practices guidelines.BMC international health and human rights · 2015Article
- Community Perspectives Associated With the African PsA-TT (MenAfriVac) Vaccine Trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Review
- Article
- Health providers' perceptions of clinical trials: lessons from Ghana, Kenya and Burkina Faso.PloS one · 2015Article
- Early phase clinical trials with human immunodeficiency virus-1 and malaria vectored vaccines in The Gambia: frontline challenges in study design and implementation.The American journal of tropical medicine and hygiene · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunization remains the most cost effective method for the control of infectious diseases. Therefore, there is a global effort to deploy new vaccines for disease control and eradication. These new vaccines must be tested in the settings in which they will be used. This necessity has required the conduct of many vaccine trials in Africa, where several infectious diseases with significant public health impact are prevalent. However, these areas have peculiarities and are just beginning to gain expertise in the conduct of such trials. The vaccine developers and sponsors of these trials may also not be conversant with some issues unique to the trial site. The understanding gap from both partners can result in challenges if not addressed during the planning phase of the trial. This review seeks to highlight the issues surrounding the conduct of clinical trials in resource-constrained settings and suggests some ways of circumventing them.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.