ArticleJournal of lipid research2013
Butein is a novel anti-adipogenic compound.
Article in Journal of lipid research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 74 citations in OpenAlex.
- Review
- Natural Chalcones for the Management of Obesity Disease.International journal of molecular sciences · 2023Review
- Screening of lactic acid bacteria with anti-adipogenic effect and potential probiotic properties from grains.Scientific reports · 2023Article
- Anti-Obesity Potential of Ponciri Fructus: Effects of Extracts, Fractions and Compounds on Adipogenesis in 3T3-L1 Preadipocytes.Molecules (Basel, Switzerland) · 2022Article
- Butein-instigated miR-186-5p-dependent modulation of TWIST1 affects resistance to cisplatin and bioenergetics of Malignant Pleural Mesothelioma cells.Cancer drug resistance (Alhambra, Calif.) · 2022Article
- Hexane Extract ofLife (Basel, Switzerland) · 2021Article
- Efficacy of a Novel Herbal Formulation (F2) on the Management of Obesity:Evidence-based complementary and alternative medicine : eCAM · 2021Article
- An alternative miRISC targets a cancer-associated coding sequence mutation in FOXL2.The EMBO journal · 2020Article
- Article
- A novel tsRNA-16902 regulating the adipogenic differentiation of human bone marrow mesenchymal stem cells.Stem cell research & therapy · 2020Article
- PPAR-Gamma as putative gene target involved in Butein mediated anti-diabetic effect.Molecular biology reports · 2020Article
- Sesamol Increases Ucp1 Expression in White Adipose Tissues and Stimulates Energy Expenditure in High-Fat Diet-Fed Obese Mice.Nutrients · 2020Article
- Butein Promotes Lineage Commitment of Bone Marrow-Derived Stem Cells into Osteoblasts via Modulating ERK1/2 Signaling Pathways.Molecules (Basel, Switzerland) · 2020Article
- Does butein affect adipogenesis?Adipocyte · 2019Article
- Identification of Phf16 and Pnpla3 as new adipogenic factors regulated by phytochemicals.Journal of cellular biochemistry · 2019Article
- Oxyresveratrol Increases Energy Expenditure through Foxo3a-Mediated Ucp1 Induction in High-Fat-Diet-Induced Obese Mice.International journal of molecular sciences · 2018Article
- PI3Ka-Akt1-mediated Prdm4 induction in adipose tissue increases energy expenditure, inhibits weight gain, and improves insulin resistance in diet-induced obese mice.Cell death & disease · 2018Article
- Butein Inhibited In Vitro Hexokinase-2-Mediated Tumor Glycolysis in Hepatocellular Carcinoma by Blocking Epidermal Growth Factor Receptor (EGFR).Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Butein activates p53 in hepatocellular carcinoma cells via blocking MDM2-mediated ubiquitination.OncoTargets and therapy · 2018Article
- Inhibitory Effects of Butein on Adipogenesis through Upregulation of the Nrf2/HO-1 Pathway in 3T3-L1 Adipocytes.Preventive nutrition and food science · 2017Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rhus verniciflua Stokes (RVS) has been used as a traditional herbal medicine for its various biological activities including anti-adipogenic effects. Activity-guided separation led to the identification of the anti-adipogenic functions of butein. Butein, a novel anti-adipogenic compound, robustly suppressed lipid accumulation and inhibited expression of adipogenic markers. Molecular studies showed that activated transforming growth factor-β (TGF-β) and suppressed signal transducer and activator of transcription 3 (STAT3) signaling pathways were mediated by butein. Analysis of the temporal expression profiles suggests that TGF-β signaling precedes the STAT3 in the butein-mediated anti-adipogenic cascade. Small interfering RNA-mediated silencing of STAT3 or SMAD2/3 blunted the inhibitory effects of butein on adipogenesis indicating that an interaction between two signaling pathways is required for the action of butein. Upon butein treatments, stimulation of TGF-β signaling was still preserved in STAT3 silenced cells, whereas regulation of STAT3 signaling by butein was significantly impaired in SMAD2/3 silenced cells, further showing that TGF-β acts upstream of STAT3 in the butein-mediated anti-adipogenesis. Taken together, the present study shows that butein, a novel anti-adipogenic compound from RVS, inhibits adipocyte differentiation through the TGF-β pathway followed by STAT3 and peroxisome proliferator-activated receptor γ signaling, further implicating potential roles of butein in TGF-β- and STAT3-dysregulated diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.