Trial reportPsychopharmacology2013
Family history of alcoholism interacts with alcohol to affect brain regions involved in behavioral inhibition.
Trial report in Psychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Meta-analysis and review of functional neuroimaging differences underlying adolescent vulnerability to substance use.NeuroImage · 2020Pooled it
- Aversion-resistant alcohol seeking in the human laboratory.Alcohol, clinical & experimental research · 2025Trial
- Subjective response to alcohol in young adults with bipolar disorder and recent alcohol use: a within-subject randomized placebo-controlled alcohol administration study.Psychopharmacology · 2023Trial
- Neural correlates of inhibitory control are associated with stimulant-like effects of alcohol.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- Associations Between Behavioral and Neural Correlates of Inhibitory Control and Amphetamine Reward Sensitivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Dose-dependent effects of intravenous alcohol administration on cerebral blood flow in young adults.Psychopharmacology · 2015Trial
- Moderating effect of working memory capacity on acute alcohol effects on BOLD response during inhibition and error monitoring in male heavy drinkers.Psychopharmacology · 2015Trial
- Alcohol-induced impairment of inhibitory control is linked to attenuated brain responses in right fronto-temporal cortex.Biological psychiatry · 2014Trial
- Neural Correlates of Inhibitory Control in Impulsivity Traits in Non-Ecological Human-Computer Tasks: An ALE Meta-Analysis.Brain sciences · 2026Review
- Variation of Myelin-associated Gene Expression andbioRxiv : the preprint server for biology · 2025Article
- Inhibitory control in the sober state as a function of alcohol sensitivity: a pilot functional magnetic resonance imaging (fMRI) study.Frontiers in human neuroscience · 2025Article
- Greater ventral striatal functional connectivity in cigarette smokers relative to non-smokers across a spectrum of alcohol consumption.Brain imaging and behavior · 2024Article
- The disengaging brain: Dynamic transitions from cognitive engagement and alcoholism risk.NeuroImage · 2020Article
- Linking Delay Discounting and Substance Use Disorders: Genotypes and Phenotypes.Perspectives on behavior science · 2019Article
- Neural oscillatory dynamics of inhibitory control in young adult binge drinkers.Biological psychology · 2019Article
- Article
- Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication.Journal of visualized experiments : JoVE · 2019Article
- Thalamic Cortical Error-Related Responses in Adult Social Drinkers: Sex Differences and Problem Alcohol Use.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Article
- Alcohol affects the P3 component of an adaptive stop signal task ERP.Alcohol (Fayetteville, N.Y.) · 2018Article
- Alcohol effects on response inhibition: Variability across tasks and individuals.Experimental and clinical psychopharmacology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleImpulsive behavior is associated with both alcohol use disorders and a family history of alcoholism (FHA). One operational definition of impulsive behavior is the stop-signal task (SST) which measures the time needed to stop a ballistic hand movement.
objectiveEmploy functional magnetic resonance imaging (fMRI) to study right frontal responses to stop signals in heavy drinking subjects with and without FHA, and as a function of alcohol exposure.
methodsTwenty-two family history-positive (FHP; age = 22.7 years, SD = 1.9) and 18 family history-negative (FHN; age = 23.7, SD = 1.8) subjects performed the SST in fMRI in two randomized visits: once during intravenous infusion of alcohol, clamped at a steady-state breath alcohol (BrAC) concentration of 60 mg/dL, and once during infusion of placebo saline. An independent reference group (n = 13, age = 23.7, SD = 1.8) was used to identify a priori right prefrontal regions activated by successful inhibition (Inh) trials, relative to "Go" trials that carried no need for inhibition [Inh > Go].
resultsFHA interacted with alcohol exposure in right prefrontal cortex, where alcohol reduced [Inh > Go] activation in FHN subjects but not in FHP subjects. Within this right frontal cortical region, stop-signal reaction time also correlated negatively with [Inh > Go] activation, suggesting that the [Inh > Go] activity was related to inhibitory behavior.
conclusionsThe results are consistent with the low level of response theory (Schuckit, J Stud Alcohol 55:149-158, 1980; Quinn and Fromme, Alcohol Clin Exp Res 35:1759-1770, 2011), with FHP being less sensitive to alcohol's effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.