ArticleEndocrine2013
Subclinical hypothyroidism is associated with elevated high-sensitive C-reactive protein among adult Taiwanese.
Article in Endocrine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Fibrinogen and D-dimer alterations in thyroid dysfunction: implications for bleeding and thrombotic risk.Thyroid research · 2026Review
- Thyrotropin exacerbates insulin resistance by triggering macrophage inflammation in subclinical hypothyroidism.Experimental & molecular medicine · 2025Article
- The role of glycemic traits in the mediation of the causal effect of hypothyroidism on coronary heart disease.Frontiers in endocrinology · 2024Article
- C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians.Diseases (Basel, Switzerland) · 2023Review
- Subclinical hypothyroidism increases insulin resistance in normoglycemic people.Frontiers in endocrinology · 2023Article
- A study of the cardiac risk factors emerging out of subclinical hypothyroidism.Journal of family medicine and primary care · 2019Article
- Thyroid disorders in Brazil: the contribution of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Article
- Decreased Leptin Is Associated with Alterations in Thyroid-Stimulating Hormone Levels after Roux-en-Y Gastric Bypass Surgery in Obese Euthyroid Patients with Type 2 Diabetes.Obesity facts · 2019Article
- The Relationship between Subclinical Thyroid Disease and Cardiovascular Disease Risk Score in Koreans.Journal of Korean medical science · 2017Article
- Thyroid Function and High-Sensitivity C-Reactive Protein in Cross-Sectional Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): Effect of Adiposity and Insulin Resistance.European thyroid journal · 2016Article
- Study on Subclinical Hypothyroidism and its Association with Various Inflammatory Markers.Journal of clinical and diagnostic research : JCDR · 2015Article
- Article
- The relationship between TSH and systemic inflammation in extremely preterm newborns.Endocrine · 2015Article
- Are preterm newborns who have relative hyperthyrotropinemia at increased risk of brain damage?Journal of pediatric endocrinology & metabolism : JPEM · 2014Article
- Serum homocysteine level is positively associated with chronic kidney disease in a Taiwan Chinese population.Journal of nephrology · 2014Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subjects with subclinical hypothyroidism (SCH) are at increased risk for cardiovascular disease (CVD). High-sensitivity C-reactive protein (hsCRP) is one of the inflammatory markers related to CVD. It is unclear whether inflammation is a mechanistic intermediary between SCH and CVD. We aimed to investigate the association between SCH and hsCRP in a Taiwanese population. A baseline cohort of 2,494 participants over the age of 19 was recruited in Taiwan from 2006 to 2008. SCH was defined as a serum thyroid-stimulating hormone (TSH) level of 5.61-19.9 mIU/L with normal thyroxine concentrations (a total T4 level of 4.9-12.0 μg/dL). Euthyroidism was defined as a serum TSH level of 0.34-5.60 mIU/L. HsCPR was grouped using quartiles. Multiple logistic and linear regression analyses were used to evaluate the relationship between hsCRP and SCH. After adjusting for gender and betel nut chewing, stepwise multiple logistic regression analyses revealed that hsCRP groups were significantly associated with SCH. Compared to the lowest hsCRP quartile, the adjusted odds ratio of having SCH for hsCRP quartile II, III, and IV were 1.38 (0.48-3.98), 1.48 (0.56-3.96), and 2.59 (1.01-6.67), respectively. The significant increase in odds ratios for SCH in progressive hsCRP quartiles reveals a dose-response effect (p < 0.05). Moreover, stepwise multiple linear regression analyses showed that hsCRP was significantly positively associated with serum TSH level after adjusting for potential confounders. Adult Taiwanese with SCH were associated with elevated hsCRP quartiles.
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