Evidence map›Paper›PMID 23468069›Full record

ArticleJournal of autism and developmental disorders2013

Trajectories of diurnal cortisol in mothers of children with autism and other developmental disabilities: relations to health and mental health.

Elisabeth M Dykens, Warren Lambert

Open access · greenAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
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  7. Article
  8. Article
  9. Adolescent effects on mothers' bedtime cortisol: Cognitive interference as a mediating mechanism.Stress and health : journal of the International Society for the Investigation of Stress · 2022
    Article
  10. Article
  11. Article
  12. Prenatal Risk for ASD: Fetal Cortisol Exposure Predicts Child Autism-Spectrum Disorder Symptoms.Clinical psychological science : a journal of the Association for Psychological Science · 2019
    Article
  13. Article
  14. Article
  15. Article
  16. Life Satisfaction Among Mothers of Individuals with Prader-Willi Syndrome.Journal of autism and developmental disorders · 2016
    Article
  17. Article
  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elisabeth M DykensDepartments of Psychology and Human Development, Pediatrics and Psychiatry, Vanderbilt Kennedy Center, Vanderbilt University, One Magnolia Circle, Peabody Box 40, Nashville, TN, 37203, USA, elisabeth.dykens@vanderbilt.edu.
Warren Lambert
John F. Kennedy Center for the Performing Arts · US

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
THREE-TIERED PREVENTION MODEL TO BETTER SERVE ALL STUDENP30HD015052 · NICHD · VANDERBILT UNIVERSITY · PI DYKENS, ELISABETH MAY · 1985 to 2014
$18.6M
Predicting Phenotypic Trajectories in Prader-Willi SyndromeR01HD035684 · NICHD · VANDERBILT UNIVERSITY · PI DYKENS, ELISABETH MAY · 1997 to 2014
$3.3M
NCRR NIH HHS UL1 RR024975NCRR NIH HHS UL1RR024975-01NICHD NIH HHS P30 HD015052NICHD NIH HHS P30HD015052NICHD NIH HHS R01 HD035684NICHD NIH HHS R01HD035684
6 · The paper itself

Abstract

This study used a stress biomarker, diurnal cortisol, to identify how elevated stress in mothers of children and adults with autism and other disabilities relates to their health and mental health. Based on semi-parametric, group-based trajectory analysis of 91 mothers, two distinctive cortisol trajectories emerged: blunted (63 %) or steep (37 %). Mothers in the blunted (vs. steep) trajectory had higher stress levels, lower health ratings, and 89 % of mothers of children with autism, and 53 % with other disabilities, belonged to this trajectory. Atypical cortisol awakening responses and evening rises were differentially associated with anxiety, depression, health problems and employment status. Stress-reducing interventions are needed for parents of children with autism and other disabilities that include biomarkers as indices of risk or treatment outcome.

Indexed as

Circadian RhythmAdultAnxietyAutistic DisorderChildDepressionDevelopmental DisabilitiesFemaleHumansHydrocortisoneMaleMental HealthMiddle AgedMothersStress, PsychologicalYoung AdultHydrocortisone

Identifiers

PMID23468069
PMCPMC4054692
OpenAlexW1987950387

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.