ReviewNeuromolecular medicine2013
Epigenetic factors and autism spectrum disorders.
Review in Neuromolecular medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Broader autism phenotype, the default mode network, and brain entropy: A network-level hypothesis.Research in neurodiversity · 2026Article
- Epigenetic Alterations in Hepatocellular Carcinoma: Mechanisms, Biomarkers, and Therapeutic Implications.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Intrathecal injection of bone marrow concentrate in children with autism spectrum disorder: a retrospective chart analysis.Frontiers in medicine · 2025Article
- Pathophysiologic similarities between autism spectrum disorder and Alzheimer's disease: therapeutic possibilities.Frontiers in neuroscience · 2025Article
- UBE3A: The Role in Autism Spectrum Disorders (ASDs) and a Potential Candidate for Biomarker Studies and Designing Therapeutic Strategies.Diseases (Basel, Switzerland) · 2023Review
- Intergenerational longitudinal associations between parental reading/musical traits, infants' auditory processing, and later phonological awareness skills.Frontiers in neuroscience · 2023Article
- Epigenetic control and genomic imprinting dynamics of the Dlk1-Dio3 domain.Frontiers in cell and developmental biology · 2023Review
- Maternal tobacco smoking and offspring autism spectrum disorder or traits in ECHO cohorts.Autism research : official journal of the International Society for Autism Research · 2022Article
- Paternal-but Not Maternal-Autistic Traits Predict Frontal EEG Alpha Asymmetry in Infants with Later Symptoms of Autism.Brain sciences · 2019Article
- Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development.Autism : the international journal of research and practice · 2019Article
- Salivary biomarkers for the diagnosis and monitoring of neurological diseases.Biomedical journal · 2018Review
- The putative role of environmental aluminium in the development of chronic neuropathology in adults and children. How strong is the evidence and what could be the mechanisms involved?Metabolic brain disease · 2017Review
- A de novo splice site mutation in EHMT1 resulting in Kleefstra syndrome with pharmacogenomics screening and behavior therapy for regressive behaviors.Molecular genetics & genomic medicine · 2017Article
- Differential methylation at the RELN gene promoter in temporal cortex from autistic and typically developing post-puberal subjects.Journal of neurodevelopmental disorders · 2016Article
- Losing the sugar coating: potential impact of perineuronal net abnormalities on interneurons in schizophrenia.Schizophrenia research · 2015Review
- Broad autism phenotype features of Chinese parents with autistic children and their associations with severity of social impairment in probands.BMC psychiatry · 2015Article
- In Pursuit of New Imprinting Syndromes by Epimutation Screening in Idiopathic Neurodevelopmental Disorder Patients.BioMed research international · 2015Article
- Gastrointestinal symptoms and autism spectrum disorder: links and risks - a possible new overlap syndrome.Pediatric health, medicine and therapeutics · 2015Review
- Review
- No increase in autism-associated genetic events in children conceived by assisted reproduction.Fertility and sterility · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism is a complex neurodevelopmental disorder that has significant phenotypic overlap with several diseases, many of which fall within the broader category of autism spectrum disorders (ASDs). The etiology of the disorder is unclear and seems to involve a complex interplay of polygenic as well as environmental factors. We discuss evidence that suggests that epigenetic dysregulation is highly implicated as a contributing cause of ASDs and autism. Specifically, we examine neurodevelopmental disorders that share significant phenotypic overlap with ASDs and feature the dysregulation of epigenetically modified genes including UBE3A, GABA receptor genes, and RELN. We then look at the dysregulated expression of implicated epigenetic modifiers, namely MeCP2, that yield complex and varied downstream pleiotropic effects. Finally, we examine epigenetically mediated parent-of-origin effects through which paternal gene expression dominates that of maternal contributing to contrasting phenotypes implicated in ASDs. Such preliminary evidence suggests that elucidating the complex role of epigenetic regulations involved in ASDs could prove vital in furthering our understanding of the complex etiology of autism and ASDs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.