ArticleMolecular and cellular biochemistry2013
MicroRNA-1 prevents high-fat diet-induced endothelial permeability in apoE knock-out mice.
Article in Molecular and cellular biochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Identifying circulating microRNAs as biomarkers of cardiovascular disease: a systematic review.Cardiovascular research · 2016Pooled it
- Circulating exosomal miRNA in acute coronary syndrome: mechanisms, clinical relevance and future directions.Frontiers in molecular biosciences · 2026Review
- Mapping novel QTL and fine mapping of previously identified QTL associated with glucose tolerance using the collaborative cross mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
- microRNA-1-3p and T-synthase mRNA have high diagnostic efficacy on intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis.The Kaohsiung journal of medical sciences · 2023Article
- MicroRNAs in cardiovascular diseases.Medical review (2021) · 2022Review
- Cardiovascular Exosomes and MicroRNAs in Cardiovascular Physiology and Pathophysiology.Journal of cardiovascular translational research · 2021Review
- Synergistic effects of EMPs and PMPs on pulmonary vascular leakage and lung injury after ischemia/reperfusion.Cell communication and signaling : CCS · 2020Article
- miR-1 induces endothelial dysfunction in rat pulmonary arteries.Journal of physiology and biochemistry · 2019Article
- Atherosclerosis and flow: roles of epigenetic modulation in vascular endothelium.Journal of biomedical science · 2019Review
- Glabridin attenuates endothelial dysfunction and permeability, possibly via the MLCK/p-MLC signaling pathway.Experimental and therapeutic medicine · 2019Article
- Protein-bounded uremic toxin p-cresylsulfate induces vascular permeability alternations.Histochemistry and cell biology · 2018Article
- MicroRNA expression profile of human advanced coronary atherosclerotic plaques.Scientific reports · 2018Article
- Cerebrovascular Pathology in Hypertriglyceridemic APOB-100 Transgenic Mice.Frontiers in cellular neuroscience · 2018Article
- Endothelial glycocalyx, apoptosis and inflammation in an atherosclerotic mouse model.Atherosclerosis · 2016Article
- Salvianolic Acid B Restored Impaired Barrier Function via Downregulation of MLCK by microRNA-1 in Rat Colitis Model.Frontiers in pharmacology · 2016Article
- The diagnostic value of circulating microRNAs for middle-aged (40-60-year-old) coronary artery disease patients.Clinics (Sao Paulo, Brazil) · 2015Article
- Circulating miR-765 and miR-149: potential noninvasive diagnostic biomarkers for geriatric coronary artery disease patients.BioMed research international · 2015Article
- Distinct gene signatures in aortic tissue from ApoE-/- mice exposed to pathogens or Western diet.BMC genomics · 2014Article
- The role of intrinsic apoptotic signaling in hemorrhagic shock-induced microvascular endothelial cell barrier dysfunction.Journal of cardiovascular translational research · 2014Review
- Role of flow-sensitive microRNAs in endothelial dysfunction and atherosclerosis: mechanosensitive athero-miRs.Arteriosclerosis, thrombosis, and vascular biology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of atherosclerosis (AS) is a multifactorial process in which elevated plasma cholesterol levels play a central role. As a new class of players involved in AS, the regulation and function of microRNAs (miR) in response to AS remain poorly understood. This study analyzed the effects of miR-1 (antagomir and mimic) on endothelial permeability and myosin light chain kinase (MLCK) expression and activity in the artery wall of apoE knock-out mice after feeding them a high-cholesterol diet. Further, we tested to determine whether that effects are involved in ERK phosphorylation. Here, we show that a high-cholesterol diet induces a significant decrease of miR-1 expression. Histopathologic examination demonstrated that miR-1 antagomir enhances endothelial permeability induced by high cholesterol and miR-1 mimic attenuated endothelial barrier dysfunction. Consistent with endothelial permeability, Western blotting, qPCR, and γ-(32)P-ATP phosphate incorporation showed that MLCK expression and activity were further increased in miR-1 antagomir-treated mice and decreased in miR-1 mimic-treated mice compared with those of mice receiving control miR. Further mechanistic studies showed that high-cholesterol-induced extracellular signal regulated kinase (ERK) activation was enhanced by miR-1 antagomir and attenuated by miR-1 mimic. Collectively, those results indicate that miR-1 contributes to endothelial barrier function via mechanisms involving not only MLCK expression and activity but also ERK phosphorylation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.