ArticleCellular and molecular neurobiology2013
Methadone-induced hypoglycemia.
Article in Cellular and molecular neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Diazoxide as a bridging therapy in methadone-induced hypoglycemia- a case report and review of the literature.Cardiovascular diabetology. Endocrinology reports · 2025Article
- A Review of the Prospective Effects of Methadone on Peripheral Neuropathic Pain in Diabetic Patients.TheScientificWorldJournal · 2025Review
- Article
- Drug-induced hyperinsulinemic hypoglycemia: An update on pathophysiology and treatment.Reviews in endocrine & metabolic disorders · 2023Review
- Methadone-induced hypoglycemia: A case report.Journal of diabetes investigation · 2023Article
- Insulinoma mimic: methadone-induced hypoglycaemia.BMJ case reports · 2022Article
- The Effect of Different Opioids on Acid-Base Balance and Blood Gas Analysis in Hospitalized Dogs.Frontiers in veterinary science · 2022Article
- Article
- The effect of methadone on blood glucose, lipids and glucose-modulating hormones in methadone-dependent Wistar rats.Toxicological research · 2020Article
- Metabolic and Addiction Indices in Patients on Opioid Agonist Medication-Assisted Treatment: A Comparison of Buprenorphine and Methadone.Scientific reports · 2020Article
- Retrospective analysis reveals significant association of hypoglycemia with tramadol and methadone in contrast to other opioids.Scientific reports · 2019Article
- Hypoglycaemia without diabetes encountered by emergency medical services: a retrospective cohort study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2018Article
- A case report of methadone-associated hypoglycemia in an 11-month-old male.Clinical toxicology (Philadelphia, Pa.) · 2018Article
- Substance Use Disorders among Patients with Type 2 Diabetes: a Dangerous but Understudied Combination.Current diabetes reports · 2017Review
- Hypoglycemic effects of tramadol analgesia in hospitalized patients: a case-control study.Journal of diabetes and metabolic disorders · 2017Article
- Methadone Use and the Risk of Hypoglycemia for Inpatients With Cancer Pain.Journal of pain and symptom management · 2016Observational
- Stabilization of morphine tolerance with long-term dosing: association with selective upregulation of mu-opioid receptor splice variant mRNAs.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Opiate pharmacology and relief of pain.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
To determine if recent observations of hypoglycemia in patients receiving high-dose methadone extended to an animal model, we explored the effects of methadone and other mu-opioids on blood glucose levels in mice. Methadone lowered blood glucose in a dose-dependent manner with 20 mg/kg yielding a nadir in average glucose levels to 55 ± 6 mg/dL from a baseline of 172 ± 7 mg/dL, an effect that was antagonized by naloxone and mu selective antagonists β-funaltrexamine and naloxonazine. The effect was stereoselective and limited to only the l-isomer, while the d-isomer was ineffective. Despite the robust decrease in blood glucose produced by methadone, a series of other mu-opioids, including morphine, fentanyl, levorphanol, oxycodone or morphine-6β-glucuronide failed to lower blood glucose levels. Similar differences among mu-opioid agonists have been observed in other systems, suggesting the possible role of selected splice variants of the mu-opioid receptor gene Oprm1. This mouse model recapitulates our clinical observations and emphasizes the need to carefully monitor glucose levels when using high methadone doses, particularly intravenously, and the need for controlled clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.