ArticleIranian journal of microbiology2013
Evaluation of ELISA and Brucellacapt tests for diagnosis of human Brucellosis.
Article in Iranian journal of microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Diagnosis of human brucellosis: Systematic review and meta-analysis.PLoS neglected tropical diseases · 2024Pooled it
- Brucellosis in the omics era: integrative perspectives on Brucella genomic architecture, host-pathogen interactions, and disease dynamics.World journal of microbiology & biotechnology · 2025Review
- Comparative Evaluation of Diagnostic Tests for Brucellosis in Humans and Animals: A Meta-Analytical Approach.Veterinary sciences · 2025Article
- Establishment of an I-ELISA method based on multi-epitope fusion protein for diagnosis of human brucellosis.PLoS neglected tropical diseases · 2025Article
- Brucellosis Seropositivity Using Three Serological Tests and Associated Risk Factors in Abattoir Workers in Gauteng Province, South Africa.Pathogens (Basel, Switzerland) · 2024Article
- Evaluating the efficacy of serological testing of clinical specimens collected from patients with suspected brucellosis.PLoS neglected tropical diseases · 2023Article
- A Comprehensive Review of the Protein Subunit Vaccines Against COVID-19.Frontiers in microbiology · 2022Review
- Knowledge of Brucellosis, Health-Seeking Behaviour, and Risk Factors forPathogens (Basel, Switzerland) · 2021Article
- Seroepidemiological survey of brucellosis and Q fever among high-risk occupations in northeast of Iran for first time.Iranian journal of microbiology · 2021Article
- Serological and molecular investigation of human brucellosis in participants of Famenin brucellosis cohort study, Hamadan, Iran.Iranian journal of microbiology · 2021Article
- Bovine brucellosis - a comprehensive review.The veterinary quarterly · 2021Review
- Development and validation of immunoassay for whole cell detection of Brucella abortus and Brucella melitensis.Scientific reports · 2020Article
- Comparison of a New and Rapid Method: Brucella Coombs Gel Test With Other Diagnostic Tests.Journal of clinical laboratory analysis · 2016Article
- A novel multi-epitope recombined protein for diagnosis of human brucellosis.BMC infectious diseases · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesBrucellosis is one of the most common zoonotic diseases in Iran and human brucellosis is endemic in all parts of the country. Because of the difficulty in the diagnosis of brucellosis, particularly in endemic areas, the use of new and feasible diagnostic tests seem to be of great importance for resolving the diagnostic obstacles. We evaluated the usefulness of a new serological test based on an immunocapture-agglutination technique in comparison with ELISA test for serological diagnosis of brucellosis. MATERIALS AND
methodsA total of 11 patients with brucellosis, who had positive blood cultures for Brucella species, and 47 suspected patients were included in this study. Serum samples collected from these patients were tested by brucellacapt and ELISA and the results were, consequently, compared.
resultsIn patients with positive blood culture, all the samples gave positive results with brucellacapt test while IgM ELISA, IgG ELISA and (IgG + IgM) ELISA tests were positive in 8, 9 and 11 patients, respectively. Out of the 46 suspected patients, (IgG + IgM) ELISA, Brucellacapt, IgG ELISA and IgM ELISA were positive in 37, 15, 34 and 37 patients, respectively.The best cut-off point of ELISA-IgG was 10.78 IU/ml which produced the maximal sensitivity and specificity for the diagnosis of human brucellosis.
conclusionBoth the (IgG + IgM) ELISA and Brucellacapt tests demonstrate a high specificity in this study. According to the results of the current study, it is found that both tests are valuable tools for diagnosis of brucellosis in Iran as an endemic area of brucellosis. It is strongly suggested that a combination of both tests to be used for the diagnosis of brucellosis.
Indexed as
Identifiers
23467496PMC3577553W2152083757What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.