ArticleAmerican journal of physiology. Renal physiology2013
HIV compromises integrity of the podocyte actin cytoskeleton through downregulation of the vitamin D receptor.
Article in American journal of physiology. Renal physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Magnetic resonance imaging features of canine intradural/extramedullary intervertebral disc extrusion in seven cases.Frontiers in veterinary science · 2022Article
- Implications of Oxidative Stress and Potential Role of Mitochondrial Dysfunction in COVID-19: Therapeutic Effects of Vitamin D.Antioxidants (Basel, Switzerland) · 2020Review
- Disruption of APOL1-miR193a Axis Induces Disorganization of Podocyte Actin Cytoskeleton.Scientific reports · 2019Article
- Impact ofFrontiers in immunology · 2019Article
- Role of Apolipoprotein L1 in Human Parietal Epithelial Cell Transition.The American journal of pathology · 2018Article
- Vitamin D Receptor: A Novel Therapeutic Target for Kidney Diseases.Current medicinal chemistry · 2018Review
- Molecular Mechanisms of Proteinuria in Focal Segmental Glomerulosclerosis.Frontiers in medicine · 2018Review
- APOL1 Renal Risk Variants: Fertile Soil for HIV-Associated Nephropathy.Seminars in nephrology · 2017Review
- Hedgehog pathway plays a vital role in HIV-induced epithelial-mesenchymal transition of podocyte.Experimental cell research · 2017Article
- Vitamin D receptor deficit induces activation of renin angiotensin system via SIRT1 modulation in podocytes.Experimental and molecular pathology · 2017Article
- Human cytomegalovirus infection downregulates vitamin-D receptor in mammalian cells.The Journal of steroid biochemistry and molecular biology · 2017Article
- HIV Promotes NLRP3 Inflammasome Complex Activation in Murine HIV-Associated Nephropathy.The American journal of pathology · 2016Article
- Epigenetic Modulation of Human Podocyte Vitamin D Receptor in HIV Milieu.Journal of molecular biology · 2015Article
- AT1R blockade in adverse milieus: role of SMRT and corepressor complexes.American journal of physiology. Renal physiology · 2015Article
- Vascular smooth muscle cells contribute to APOL1-induced podocyte injury in HIV milieu.Experimental and molecular pathology · 2015Article
- Hyperglycemia enhances kidney cell injury in HIVAN through down-regulation of vitamin D receptors.Cellular signalling · 2015Article
- HIV-associated nephropathies: epidemiology, pathology, mechanisms and treatment.Nature reviews. Nephrology · 2015Review
- Vitamin D receptor and epigenetics in HIV infection and drug abuse.Frontiers in microbiology · 2015Review
- Renin modulates HIV replication in T cells.Journal of leukocyte biology · 2014Article
- APOL1 risk variants enhance podocyte necrosis through compromising lysosomal membrane permeability.American journal of physiology. Renal physiology · 2014Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Alterations in the podocyte actin cytoskeleton have been implicated in the development of proteinuric kidney diseases. In the present study, we evaluated the effect of HIV on the podocyte actin cytoskeleton and the mechanism involved. We hypothesized that HIV may be compromising the actin cytoskeleton via downregulation of the vitamin D receptor (VDR) of conditionally immortalized differentiated human podocytes (CIDHPs). HIV-transduced podocytes (HIV/CIDHPs) not only displayed downregulation of VDR but also showed activation of the renin-angiotensin system (RAS) in the form of enhanced expression of renin and increased production of ANG II. Moreover, CIDHPs lacking VDR displayed enhanced ANG II production, and treatment of HIV/CIDHPs with EB1089 (vitamin D3; VD) attenuated ANG II production. HIV/CIDHPs as well as ANG II-treated CIDHPs exhibited enhanced expression of cathepsin (CTS) L. Additionally, losartan (an ANG II type I receptor blocker) inhibited both HIV- and ANG II-induced podocyte cathepsin L expression. Furthermore, VD downregulated HIV-induced podocyte CTSL expression. Both losartan and free radical scavengers attenuated HIV- and ANG II-induced podocyte reactive oxygen species (ROS) generation. HIV also led to cytosolic CTSL accumulation through enhancement of podocyte lysosomal membrane permeabilization; on the other hand, VD, losartan, and superoxide dismutase (SOD) attenuated HIV-induced enhanced podocyte cytosolic CTSL accumulation. Morphological evaluation of HIV/CIDHPs revealed sparse actin filaments and attenuated expression of dynamin. Interestingly, podocytes lacking CTSL displayed enhanced dynamin expression, and HIV/CIDHPs expressing CTSL exhibited downregulation of dynamin. These findings indicate that HIV-induced downregulation of podocyte VDR and associated RAS activation and cytosolic CTSL accumulation compromised the actin cytoskeleton.
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