ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Parkinson's disease: increased motor network activity in the absence of movement.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Brain Motor Network Changes in Parkinson's Disease: Evidence from Meta-Analytic Modeling.Movement disorders : official journal of the Movement Disorder Society · 2021Pooled it
- Functional neuroimaging of motor control in Parkinson's disease: a meta-analysis.Human brain mapping · 2014Pooled it
- Network modulation following sham surgery in Parkinson's disease.The Journal of clinical investigation · 2014Trial
- Multimodal data-driven eye-movement subtypes and their cerebral glucose metabolic patterns in Parkinson's disease.Frontiers in aging neuroscience · 2026Article
- Identification of a metabolic brain network characterizing essential tremor.Scientific reports · 2025Article
- Functional Brain Networks to Evaluate Treatment Responses in Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Deep brain stimulation has state-dependent effects on motor connectivity in Parkinson's disease.Brain : a journal of neurology · 2019Article
- Inventory of real world data sources in Parkinson's disease.BMC neurology · 2017Review
- Calcium, mitochondrial dysfunction and slowing the progression of Parkinson's disease.Experimental neurology · 2017Review
- Parkinson's Disease Is Not Simply a Prion Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
- Resting-State Hyperperfusion of the Supplementary Motor Area in Catatonia.Schizophrenia bulletin · 2017Article
- Differentiating Patients with Parkinson's Disease from Normal Controls Using Gray Matter in the Cerebellum.Cerebellum (London, England) · 2017Article
- Article
- Longitudinal Changes in the Motor Learning-Related Brain Activation Response in Presymptomatic Huntington's Disease.PloS one · 2016Article
- Neuroimaging of Parkinson's disease: Expanding views.Neuroscience and biobehavioral reviews · 2015Review
- Patterns of Cortical Synchronization in Isolated Dystonia Compared With Parkinson Disease.JAMA neurology · 2015Observational
- Impaired planning in Parkinson's disease is reflected by reduced brain activation and connectivity.Human brain mapping · 2015Article
- Effects of levodopa on regional cerebral metabolism and blood flow.Movement disorders : official journal of the Movement Disorder Society · 2015Review
- The Human Experience with Intravenous Levodopa.Frontiers in pharmacology · 2015Review
- Task-related activity in sensorimotor cortex in Parkinson's disease and essential tremor: changes in beta and gamma bands.Frontiers in human neuroscience · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We used a network approach to assess systems-level abnormalities in motor activation in humans with Parkinson's disease (PD). This was done by measuring the expression of the normal movement-related activation pattern (NMRP), a previously validated activation network deployed by healthy subjects during motor performance. In this study, NMRP expression was prospectively quantified in (15)O-water PET scans from a PD patient cohort comprised of a longitudinal early-stage group (n = 12) scanned at baseline and at two or three follow-up visits two years apart, and a moderately advanced group scanned on and off treatment with either subthalamic nucleus deep brain stimulation (n = 14) or intravenous levodopa infusion (n = 14). For each subject and condition, we measured NMRP expression during both movement and rest. Resting expression of the abnormal PD-related metabolic covariance pattern was likewise determined in the same subjects. NMRP expression was abnormally elevated (p < 0.001) in PD patients scanned in the nonmovement rest state. By contrast, network activity measured during movement did not differ from normal (p = 0.34). In the longitudinal cohort, abnormal increases in resting NMRP expression were evident at the earliest clinical stages (p < 0.05), which progressed significantly over time (p = 0.003). Analogous network changes were present at baseline in the treatment cohort (p = 0.001). These abnormalities improved with subthalamic nucleus stimulation (p < 0.005) but not levodopa (p = 0.25). In both cohorts, the changes in NMRP expression that were observed did not correlate with concurrent PD-related metabolic covariance pattern measurements (p > 0.22). Thus, the resting state in PD is characterized by changes in the activity of normal as well as pathological brain networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.