ReviewTexas Heart Institute journal2013
Components of the complete blood count as risk predictors for coronary heart disease: in-depth review and update.
Review in Texas Heart Institute journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
124 citing papers in PubMed, 1 synthesis or guideline pooled it, 182 citations in OpenAlex.
- Impact of anti-inflammatory diets on cardiovascular disease risk factors: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Regression of Coronary Fatty Plaque and Risk of Cardiac Events According to Blood Pressure Status: Data From a Randomized Trial of Eicosapentaenoic Acid and Docosahexaenoic Acid in Patients With Coronary Artery Disease.Journal of the American Heart Association · 2023Trial
- Baseline neutrophil-to-lymphocyte ratio and efficacy of SGLT2 inhibition with empagliflozin on cardiac remodelling.ESC heart failure · 2023Trial
- An indoor air filtration study in homes of elderly: cardiovascular and respiratory effects of exposure to particulate matter.Environmental health : a global access science source · 2013Trial
- The effect of eicosapentaenoic and docosahexaenoic acids on physical function, exercise, and joint replacement in patients with coronary artery disease: A secondary analysis of a randomized clinical trial.Journal of clinical lipidologyTrial
- Review
- Uncovering research themes in coronary slow flow predictors: a bibliometric and cluster analysis.Journal of cardiothoracic surgery · 2026Review
- Systemic Inflammatory Indices Predict Survival and Limb Outcomes after Revascularization for Chronic Limb-Threatening Ischemia.Journal of vascular research · 2026Article
- Development and Validation of Artificial Intelligence Prediction of Epicardial Coronary Artery Spasm in Patients Without Obstructive Coronary Artery Disease.Diagnostics (Basel, Switzerland) · 2026Article
- Article
- Association Between Neutrophil-to-Lymphocyte Ratio and Glycemic Control in Type 2 Diabetes Mellitus: An Updated Systematic Review and Meta-Analysis.Health science reports · 2026Review
- Association of plasma homocysteine with the atherogenic index of plasma and modification by body mass index: a cross-sectional study.Frontiers in cardiovascular medicine · 2026Article
- Low-Grade Inflammatory Hematological Markers in Otolaryngologic Diseases: A Preliminary Report.Diseases (Basel, Switzerland) · 2025Article
- Genetic factors for hematological traits in pigs.Animal genetics · 2025Review
- Association between baseline white blood cell count and future cardiovascular events in patients with stable coronary artery disease- Sub-analysis of the REAL-CAD trial.American journal of preventive cardiology · 2025Article
- Beyond Black Boxes: Interpretable AI with Explainable Neural Networks (ENNs) for Acute Myocardial Infarction (AMI) Using Common Hematological Parameters.Medicina (Kaunas, Lithuania) · 2025Article
- Multidisciplinary Insights into Perioperative Cardiac Events in Non-Cardiac Surgery: an ECG Holter Monitoring Study.Maedica · 2025Article
- Full Blood Count and its Differentials in Acute Aortic Dissection: An Update and Future Perspectives.Aorta (Stamford, Conn.) · 2025Article
- Role of IL-2, IL-6, and TNF-α as Potential Biomarkers in Ischemic Heart Disease: A Comparative Study of Patients with CAD and Non-CAD.Medical sciences (Basel, Switzerland) · 2025Observational
- Association of nocturnal hypoxemia and white blood cell count in a multicenter cohort.Sleep advances : a journal of the Sleep Research Society · 2025Article
64 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atherosclerosis is an inflammatory disease, and several inflammatory biomarkers, such as C-reactive protein, have been used to predict the risk of coronary heart disease. High white blood cell count is a strong and independent predictor of coronary risk in patients of both sexes, with and without coronary heart disease. A high number of white blood cells and their subtypes (for example, neutrophils, monocytes, lymphocytes, and eosinophils) are associated with the presence of coronary heart disease, peripheral arterial disease, and stroke. The coronary heart disease risk ratios associated with a high white blood cell count are comparable to those of other inflammatory markers, including C-reactive protein. In addition, other components of the complete blood count, such as hematocrit and the erythrocyte sedimentation rate, also are associated with coronary heart disease, and the combination of the complete blood count with the white blood cell count can improve our ability to predict coronary heart disease risk. These tests are inexpensive, widely available, and easy to order and interpret. They merit further research.
Indexed as
Identifiers
23467296PMC3568280W77922754What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.