Evidence map›Paper›PMID 23467280›Full record

ArticleDermato-endocrinology2012

Hyaluronic acid: A key molecule in skin aging.

Eleni Papakonstantinou, Michael Roth, George Karakiulakis

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dermato-endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 399 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
399citing papers in PubMed, 4 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

399 citing papers in PubMed, 4 syntheses or guidelines pooled it, 969 citations in OpenAlex.

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  19. High molecular weight hyaluronic acid vectorised with clay provides long-term hydration and reduces skin brightness.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Trial
  20. Ameliorative effects ofMolecular medicine reports · 2026
    Article

339 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Eleni PapakonstantinouDepartment of Pharmacology; School of Medicine; Aristotle University of Thessaloniki; Thessaloniki, Greece.
Michael Roth
George Karakiulakis
Aristotle University of Thessaloniki · GRHospital Base · CLIndiana University School of Medicine

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

skin aging is a multifactorial process consisting of two distinct and independent mechanismsintrinsic and extrinsic aging. Youthful skin retains its turgor, resilience and pliability, among others, due to its high content of water. Daily external injury, in addition to the normal process of aging, causes loss of moisture. The key molecule involved in skin moisture is hyaluronic acid (HA) that has unique capacity in retaining water. There are multiple sites for the control of HA synthesis, deposition, cell and protein association and degradation, reflecting the complexity of HA metabolism. The enzymes that synthesize or catabolize HA and HA receptors responsible for many of the functions of HA are all multigene families with distinct patterns of tissue expression. Understanding the metabolism of HA in the different layers of the skin and the interactions of HA with other skin components will facilitate the ability to modulate skin moisture in a rational manner.

Indexed as

CD44hyaluronic acidhyaluronic acid synthaseshyaluronidasesRHAMMskin aging

Identifiers

PMID23467280
PMCPMC3583886
OpenAlexW2121511326

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.