ArticleOsteoarthritis and cartilage2013
Non-terminal animal model of post-traumatic osteoarthritis induced by acute joint injury.
Article in Osteoarthritis and cartilage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Equine models in translational medicine: A comparative approach to human health.Animal models and experimental medicine · 2026Review
- Cord blood mesenchymal stromal cells combined with hyaluronic acid show symptom-modifying and potential disease-modifying effects in an equine osteoarthritis fetlock chip model.Frontiers in veterinary science · 2026Article
- Extracellular vesicles in the treatment and prevention of osteoarthritis: can horses help us translate this therapy to humans?Extracellular vesicles and circulating nucleic acids · 2023Article
- The Clinical Pharmacology and Therapeutic Evaluation of Non-Steroidal Anti-Inflammatory Drugs in Adult Horses.Animals : an open access journal from MDPI · 2023Review
- T Helper 17-Like Regulatory T Cells in Equine Synovial Fluid Are Associated With Disease Severity of Naturally Occurring Posttraumatic Osteoarthritis.The American journal of sports medicine · 2023Article
- Plantar osteochondral fragments in young Standardbreds are associated with minimal joint inflammation at the time of surgical removal.Equine veterinary journal · 2023Article
- Recombinant fibroblast growth factor-18 (sprifermin) enhances microfracture-induced cartilage healing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Evaluation of Allogeneic Bone-Marrow-Derived and Umbilical Cord Blood-Derived Mesenchymal Stem Cells to Prevent the Development of Osteoarthritis in An Equine Model.International journal of molecular sciences · 2021Article
- Mechanical Stress Induce PG-E2 in Murine Synovial Fibroblasts Originating from the Temporomandibular Joint.Cells · 2021Article
- Differential gene expression analysis reveals pathways important in early post-traumatic osteoarthritis in an equine model.BMC genomics · 2020Article
- Article
- [Experimental study on crosslinked-chitosan in treatment of knee osteoarthritis in rabbits].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2019Article
- Models of osteoarthritis: the good, the bad and the promising.Osteoarthritis and cartilage · 2019Review
- Post-traumatic osteoarthritis of the ankle: A distinct clinical entity requiring new research approaches.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Review
- Pro-inflammatory cytokines and structural biomarkers are effective to categorize osteoarthritis phenotype and progression in Standardbred racehorses over five years of racing career.BMC veterinary research · 2016Article
- A novel rabbit model of early osteoarthritis exhibits gradual cartilage degeneration after medial collateral ligament transection outside the joint capsule.Scientific reports · 2016Article
- Article
- Development of an equine groove model to induce metacarpophalangeal osteoarthritis: a pilot study on 6 horses.PloS one · 2015Article
- Specialty Grand Challenge in Veterinary Surgery and Anesthesiology.Frontiers in veterinary science · 2015Article
- Temporomandibular joint osteoarthritis: diagnosis and long-term conservative management: a topic review.Journal of Indian Prosthodontic Society · 2014Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveDevelop a non-terminal animal model of acute joint injury that demonstrates clinical and morphological evidence of early post-traumatic osteoarthritis (PTOA).
methodsAn osteochondral (OC) fragment was created arthroscopically in one metacarpophalangeal (MCP) joint of 11 horses and the contralateral joint was sham operated. Eleven additional horses served as unoperated controls. Every 2 weeks, force plate analysis, flexion response, joint circumference, and synovial effusion scores were recorded. At weeks 0 and 16, radiographs (all horses) and arthroscopic videos (OC injured and sham joints) were graded. At week 16, synovium and cartilage biopsies were taken arthroscopically from OC injured and sham joints for histologic evaluation and the OC fragment was removed.
resultsOC fragments were successfully created and horses were free of clinical lameness after fragment removal. Forelimb gait asymmetry was observed at week 2 (P = 0.0012), while joint circumference (P < 0.0001) and effusion scores (P < 0.0001) were increased in injured limbs compared to baseline from weeks 2 to 16. Positive flexion response of injured limbs was noted at multiple time points. Capsular enthesophytes were seen radiographically in injured limbs. Articular cartilage damage was demonstrated arthroscopically as mild wear-lines and histologically as superficial zone chondrocyte death accompanied by mild proliferation. Synovial hyperemia and fibrosis were present at the site of OC injury.
conclusionAcute OC injury to the MCP joint resulted in clinical, imaging, and histologic changes in cartilage and synovium characteristic of early PTOA. This model will be useful for defining biomarkers of early osteoarthritis and for monitoring response to therapy and surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.