Evidence map›Paper›PMID 23466910›Full record

ArticleInfection control and hospital epidemiology2013

Respiratory virus shedding in a cohort of on-duty healthcare workers undergoing prospective surveillance.

Jennifer C Esbenshade, Kathryn M Edwards, Adam J Esbenshade, Vanessa E Rodriguez, H Keipp Talbot, Marlon F Joseph, Samuel K Nwosu, James D Chappell, James E Gern, John V Williams and 1 more

Open access · greenAbstract read
In one paragraph

Article in Infection control and hospital epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
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  6. Article
  7. Use of whole-genome sequencing in the molecular investigation of care-associated HCoV-OC43 infections in a hematopoietic stem cell transplant unit.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2020
    Article
  8. Article
  9. Article
  10. Review
  11. Article
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  14. Healthcare workers as vectors of infectious diseases.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014
    Review
  15. Better tests, better care: improved diagnostics for infectious diseases.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jennifer C EsbenshadeDepartment of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Kathryn M Edwards
Adam J Esbenshade
Vanessa E Rodriguez
H Keipp Talbot
Marlon F Joseph
Samuel K Nwosu
James D Chappell
James E Gern
John V Williams
Thomas R Talbot
Vanderbilt University · USUniversity of Wisconsin–Madison · US

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
Conducting Child Health Care Research in Vulnerable PopulationsT32HD060554 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BARKIN, SHARI, WILLIAMS, DEREK J. · 2009 to 2019
$3.8M
Enhanced Surveillance: New Vaccine Preventable DiseasesU01IP000022 · IP · VANDERBILT UNIVERSITY · PI EDWARDS, KATHRYN MARGARET · 2004 to 2010
$3.6M
NCATS NIH HHS UL1TR000011NCI NIH HHS K12 CA090625NCIRD CDC HHS 1U01 IP000022NCIRD CDC HHS U01 IP000022NCRR NIH HHS 1 UL1 RR024975NCRR NIH HHS UL1 RR024975NIAID NIH HHS L40 AI084726NICHD NIH HHS 1T32HD060554-01NICHD NIH HHS T32 HD060554
6 · The paper itself

Abstract

backgroundHealthcare-associated transmission of respiratory viruses is a concerning patient safety issue.

designSurveillance for influenza virus among a cohort of healthcare workers (HCWs) was conducted in a tertiary care children's hospital from November 2009 through April 2010 using biweekly nasal swab specimen collection. If a subject reported respiratory symptoms, an additional specimen was collected. Specimens from ill HCWs and a randomly selected sample from asymptomatic subjects were tested for additional respiratory viruses by multiplex polymerase chain reaction (PCR).

resultsA total of 1,404 nasal swab specimens were collected from 170 enrolled subjects. Influenza circulated at very low levels during the surveillance period, and 74.2% of subjects received influenza vaccination. Influenza virus was not detected in any specimen. Multiplex respiratory virus PCR analysis of all 119 specimens from symptomatic subjects and 200 specimens from asymptomatic subjects yielded a total of 42 positive specimens, including 7 (16.7%) in asymptomatic subjects. Viral shedding was associated with report of any symptom (odds ratio [OR], 13.06 [95% confidence interval, 5.45-31.28]; [Formula: see text]) and younger age (OR, 0.96 [95% confidence interval, 0.92-0.99]; [Formula: see text]) when controlled for sex and occupation of physician or nurse. After the surveillance period, 46% of subjects reported working while ill with an influenza-like illness during the previous influenza season.

conclusionsIn this cohort, HCWs working while ill was common, as was viral shedding among those with symptoms. Asymptomatic viral shedding was infrequent but did occur. HCWs should refrain from patient care duties while ill, and staffing contingencies should accommodate them.

Indexed as

Personnel, HospitalVirus SheddingAdolescentAdultAgedAsymptomatic DiseasesCohort StudiesFemaleHospitals, PediatricHumansInfection ControlInfluenza, HumanLogistic ModelsMaleMiddle AgedMultiplex Polymerase Chain Reaction

Identifiers

PMID23466910
PMCPMC3730277
OpenAlexW2000004921

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.