ArticleInternational journal of molecular sciences2013
Mass spectrometry-based proteomics for the analysis of chromatin structure and dynamics.
Article in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
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- Lysines Acetylome and Methylome Profiling of H3 and H4 Histones in Trichostatin A-Treated Stem Cells.International journal of molecular sciences · 2021Article
- Extracting histones for the specific purpose of label-free MS.Proteomics · 2016Article
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- Pathology Tissue-quantitative Mass Spectrometry Analysis to Profile Histone Post-translational Modification Patterns in Patient Samples.Molecular & cellular proteomics : MCP · 2016Article
- Mass spectrometric quantification of histone post-translational modifications by a hybrid chemical labeling method.Molecular & cellular proteomics : MCP · 2015Article
- Quantitative proteomic analysis of histone modifications.Chemical reviews · 2015Review
- Development of a test to identify bladder cancer in the urine of patients using mass spectroscopy and subcellular localization of the detected proteins.American journal of translational research · 2015Article
- Temperature and magnetic field driven modifications in the I-V features of gold-DNA-gold structure I-V.Sensors (Basel, Switzerland) · 2014Article
- Interpreting the language of histone and DNA modifications.Biochimica et biophysica acta · 2014Review
- Advanced methods for the analysis of chromatin-associated proteins.Physiological genomics · 2014Review
- The ChroP approach combines ChIP and mass spectrometry to dissect locus-specific proteomic landscapes of chromatin.Journal of visualized experiments : JoVE · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromatin is a highly structured nucleoprotein complex made of histone proteins and DNA that controls nearly all DNA-dependent processes. Chromatin plasticity is regulated by different associated proteins, post-translational modifications on histones (hPTMs) and DNA methylation, which act in a concerted manner to enforce a specific "chromatin landscape", with a regulatory effect on gene expression. Mass Spectrometry (MS) has emerged as a powerful analytical strategy to detect histone PTMs, revealing interplays between neighbouring PTMs and enabling screens for their readers in a comprehensive and quantitative fashion. Here we provide an overview of the recent achievements of state-of-the-art mass spectrometry-based proteomics for the detailed qualitative and quantitative characterization of histone post-translational modifications, histone variants, and global interactomes at specific chromatin regions. This synopsis emphasizes how the advances in high resolution MS, from "Bottom Up" to "Top Down" analysis, together with the uptake of quantitative proteomics methods by chromatin biologists, have made MS a well-established method in the epigenetics field, enabling the acquisition of original information, highly complementary to that offered by more conventional, antibody-based, assays.
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Registered trials
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