ArticleDevelopmental biology2013
Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis.
Article in Developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- CAFs-derived lactate enhances the cancer stemness through inhibiting the MST1 ubiquitination degradation in OSCC.Cell & bioscience · 2024Article
- Article
- Decreased expression of Dlg5 is associated with a poor prognosis and epithelial-mesenchymal transition in squamous cell lung cancer.Journal of thoracic disease · 2021Article
- Cytoskeletal Organization and Cell Polarity in the Pathogenesis of Crohn's Disease.Clinical reviews in allergy & immunology · 2021Review
- Advances in Understanding the LncRNA-Mediated Regulation of the Hippo Pathway in Cancer.OncoTargets and therapy · 2021Review
- Multiple functions of the scaffold protein Discs large 5 in the control of growth, cell polarity and cell adhesion in Drosophila melanogaster.BMC developmental biology · 2020Article
- PABPC1-induced stabilization of BDNF-AS inhibits malignant progression of glioblastoma cells through STAU1-mediated decay.Cell death & disease · 2020Article
- The polarity protein Dlg5 regulates collective cell migration during Drosophila oogenesis.PloS one · 2019Article
- Lineage Specification from Prostate Progenitor Cells Requires Gata3-Dependent Mitotic Spindle Orientation.Stem cell reports · 2017Article
- DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.Genes & development · 2016Article
- Dlg5 maintains apical polarity by promoting membrane localization of Crumbs during Drosophila oogenesis.Scientific reports · 2016Article
- Oriented cell division: new roles in guiding skin wound repair and regeneration.Bioscience reports · 2015Review
- The pulmonary mesenchyme directs lung development.Current opinion in genetics & development · 2015Review
- Loss of Dlg5 expression promotes the migration and invasion of prostate cancer cells via Girdin phosphorylation.Oncogene · 2015Article
- Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.Genes & development · 2015Article
- Article
- DLG5 in cell polarity maintenance and cancer development.International journal of biological sciences · 2014Review
- Sox9 plays multiple roles in the lung epithelium during branching morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Lung epithelial branching program antagonizes alveolar differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Spindle orientation and epidermal morphogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Cell polarity plays an important role in tissue morphogenesis; however, the mechanisms of polarity and their role in mammalian development are still poorly understood. We show here that membrane-associated guanylate kinase protein Dlg5 is required for proper branching morphogenesis and progenitor differentiation in mammalian lung. We found that during lung development Dlg5 functions as an apical-basal polarity protein, which is necessary for the apical maintenance of atypical protein kinase C (aPKC). These results identify Dlg5 as a regulator of apical polarity complexes and uncover the critical function of Dlg5 in branching morphogenesis and differentiation of lung progenitor cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.