ArticleBehavioural brain research2013
Decreased frontal N-acetylaspartate levels in adolescents concurrently using both methamphetamine and marijuana.
Article in Behavioural brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Spectroscopic meta-analyses reveal novel metabolite profiles across methamphetamine and cocaine substance use disorder.Drug and alcohol dependence · 2023Pooled it
- The Utility of Magnetic Resonance Spectroscopy for Understanding Substance Use Disorders: A Systematic Review of the Literature.Journal of the American Psychiatric Nurses AssociationPooled it
- Reduced responsiveness of the reward system is associated with tolerance to cannabis impairment in chronic users.Addiction biology · 2021Trial
- Delta-9-tetrahydrocannabinol increases striatal glutamate levels in healthy individuals: implications for psychosis.Molecular psychiatry · 2020Trial
- What Do Thirty Years of Neuroimaging Research Tell Us About Recreational Cannabis Use and Brain Integrity? A Narrative Review of the Multimodal Neuroimaging Evidence to Date.Substance abuse and rehabilitation · 2026Review
- Cannabinoids: Role in Neurological Diseases and Psychiatric Disorders.International journal of molecular sciences · 2024Review
- Imaging neuroinflammation in individuals with substance use disorders.The Journal of clinical investigation · 2024Review
- Impact of cannabis use on brain metabolism usingNeuroradiology · 2023Article
- Article
- Co-exposure of cannabinoids with amphetamines and biological, behavioural and health outcomes: a scoping review of animal and human studies.Psychopharmacology · 2022Article
- Effects of cannabinoid exposure on short-term memory and medial orbitofrontal cortex function and chemistry in adolescent female rhesus macaques.Frontiers in neuroscience · 2022Article
- The neurobiology of wellness:NeuroImage · 2021Article
- Multiple Substance Use Disorders and Self-Reported Cognitive Function in U.S. Adults: Associations and Sex-Differences in a Nationally Representative Sample.Frontiers in psychiatry · 2021Article
- Early treatment response in first episode psychosis: a 7-T magnetic resonance spectroscopic study of glutathione and glutamate.Molecular psychiatry · 2020Article
- Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review.Molecular neuropsychiatry · 2019Review
- The neuropsychopharmacology of cannabis: A review of human imaging studies.Pharmacology & therapeutics · 2019Review
- CNS metabolism in high-risk drug abuse : Insights gained fromDer Radiologe · 2018Review
- Metabolic alterations in the anterior cingulate cortex and related cognitive deficits in late adolescent methamphetamine users.Addiction biology · 2018Article
- [CNS metabolism in high-risk drug abuse, German version : Insights gained fromDer Radiologe · 2017Review
- Neurobiological signatures associated with alcohol and drug use in the human adolescent brain.Neuroscience and biobehavioral reviews · 2016Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
introductionThe potential neurochemical toxicity associated with methamphetamine (MA) or marijuana (MJ) use on the developing adolescent brain is unclear, particularly with regard to individuals with concomitant use of MA and MJ (MA+MJ). In this study, proton magnetic resonance spectroscopy (MRS) was utilized to measure in vivo brain N-acetylaspartate plus N-acetylaspartyl glutamate (tNAA, an indicator of intact neuronal integrity) levels.
methodsThree adolescent groups from Cape Town, South Africa completed MRS scans as well as clinical measures including a drug use history. Subjects included (1) nine MA (age=15.7±1.37), (2) eight MA+MJ (age=16.2±1.16) using adolescents and (3) ten healthy controls (age=16.8±0.62). Single voxel spectra were acquired from midfrontal gray matter using a point-resolved spectroscopy sequence (PRESS). The MRS data were post-processed in the fully automated approach for quantitation of metabolite ratios to phosphocreatine plus creatine (PCr+Cr).
resultsA significant reduction in frontal tNAA/PCr+Cr ratios was seen in the MA+MJ group compared to the healthy controls (p=0.01, by 7.2%) and to the MA group (p=0.04, by 6.9%). Significant relationships were also observed between decreased tNAA/PCr+Cr ratios and drug use history of MA or MJ (total cumulative lifetime dose, age of onset, and duration of MA and MJ exposure) only in the MA+MJ group (all p<0.05).
conclusionsThese findings suggest that in adolescents, concomitant heavy MA+MJ use may contribute to altered brain metabolites in frontal gray matter. The significant associations between the abnormal tNAA/PCr+Cr ratios and the drug use history suggest that MA+MJ abuse may induce neurotoxicity in a dose-responsive manner in adolescent brain.
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