ArticleScientific reports2013
SOXC transcription factors in mantle cell lymphoma: the role of promoter methylation in SOX11 expression.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- miR-221 activates Sox11 to reduce brain injury after intracerebral hemorrhage via inhibiting neuroinflammation.Scientific reports · 2025Article
- Hypomethylation-associated Sox11 upregulation promotes oncogenesis via the PI3K/AKT pathway in OLP-associated OSCC.Journal of cellular and molecular medicine · 2024Article
- Systematic Investigation of the Multifaceted Role ofCancers · 2022Article
- Progress in molecular feature of smoldering mantle cell lymphoma.Experimental hematology & oncology · 2021Review
- Impact of SRY-Box Transcription Factor 11 Gene Polymorphisms on Oral Cancer Risk and Clinicopathologic Characteristics.International journal of molecular sciences · 2020Article
- Highly sensitive and specificHaematologica · 2020Article
- SOX11: friend or foe in tumor prevention and carcinogenesis?Therapeutic advances in medical oncology · 2019Review
- DNA methylation inhibitor causes cell growth retardation and gene expression changes in feline lymphoma cells.The Journal of veterinary medical science · 2017Article
- The transcriptional coregulator MAML1 affects DNA methylation and gene expression patterns in human embryonic kidney cells.Molecular biology reports · 2016Article
- Aberrant SOX11 promoter methylation is associated with poor prognosis in gastric cancer.Cellular oncology (Dordrecht, Netherlands) · 2015Article
- DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells.BMC cancer · 2015Article
- Evolutionarily conserved role for SoxC genes in neural crest specification and neuronal differentiation.Developmental biology · 2015Article
- Risk factors for etiology and prognosis of mantle cell lymphoma.Expert review of hematology · 2014Review
- Cobblestone-area forming cells derived from patients with mantle cell lymphoma are enriched for CD133+ tumor-initiating cells.PloS one · 2014Article
- Sox11 Modified Tendon-Derived Stem Cells Promote the Repair of Osteonecrosis of Femoral Head.Cell transplantationArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The related transcription factors SOX11, SOX4 and SOX12 (classified as the SOXC family) compete for the same target genes. SOX11 is expressed in most mantle cell lymphomas (MCL) but a small subset is, like normal lymphocytes, SOX11 negative. Here we report the variable expression of SOX4 and high expression of SOX12 in MCL compared to non-malignant tissue. Our results show that the expression of the SOXC genes is highly correlated in SOX11 positive MCL. SOX11 expression is epigenetically regulated but there are partly conflicting results regarding the underlying mechanisms. Here we report that the SOX11 promoter region is hypomethylated in both MCL and normal B-lymphocytes. Methylation at other sites is important for sustaining high SOX11 in MCL since treatment with 5-azacytidine decreased SOX11 levels in SOX11 positive MCL cell lines: Granta519 and Rec1. Furthermore, 5-azacytidine treatment of the SOX11 negative MCL cell line, JVM2, induced SOX4 but not SOX11.
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