ArticleBone2013
PTH prevents the adverse effects of focal radiation on bone architecture in young rats.
Article in Bone, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- Review
- Orchestrated delivery of PTH [1-34] followed by zoledronic acid prevents radiotherapy-induced bone loss but does not abrogate marrow damage.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Parathyroid hormone promotes the osteogenesis of lipopolysaccharide-induced human bone marrow mesenchymal stem cells through the JNK MAPK pathway.Bioscience reports · 2021Article
- Parathyroid Hormone 1 Receptor Signaling in Dental Mesenchymal Stem Cells: Basic and Clinical Implications.Frontiers in cell and developmental biology · 2021Review
- Postradiation Fractures after Combined Modality Treatment in Extremity Soft Tissue Sarcomas.Sarcoma · 2021Review
- Evaluation of longitudinal time-lapsed in vivo micro-CT for monitoring fracture healing in mouse femur defect models.Scientific reports · 2019Article
- Periosteal Mesenchymal Progenitor Dysfunction and Extraskeletally-Derived Fibrosis Contribute to Atrophic Fracture Nonunion.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Article
- What Is the Effect of High-dose Radiation on Bone in Patients With Sacral Chordoma? A CT Study.Clinical orthopaedics and related research · 2018Article
- Proteasome inhibitor bortezomib is a novel therapeutic agent for focal radiation-induced osteoporosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Limited field radiation therapy results in decreased bone fracture toughness in a murine model.PloS one · 2018Article
- Longitudinal Effects of Single Hindlimb Radiation Therapy on Bone Strength and Morphology at Local and Contralateral Sites.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Article
- Dosimetry in Micro-computed Tomography: a Review of the Measurement Methods, Impacts, and Characterization of the Quantum GX Imaging System.Molecular imaging and biology · 2017Review
- PTH(1-34) and zoledronic acid have differing longitudinal effects on juvenile mouse femur strength and morphology.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Increased EZH2 and decreased osteoblastogenesis during local irradiation-induced bone loss in rats.Scientific reports · 2016Article
- Parathyroid Hormone (1-34) Transiently Protects Against Radiation-Induced Bone Fragility.Calcified tissue international · 2016Article
- Article
- Article
- Mechanical Loading Attenuates Radiation-Induced Bone Loss in Bone Marrow Transplanted Mice.PloS one · 2016Article
- Quantification of skeletal growth, modeling, and remodeling by in vivo micro computed tomography.Bone · 2015Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Radiation therapy is a common treatment regimen for cancer patients. However, its adverse effects on the neighboring bone could lead to fractures with a great impact on quality of life. The underlying mechanism is still elusive and there is no preventive or curative solution for this bone loss. Parathyroid hormone (PTH) is a current therapy for osteoporosis that has potent anabolic effects on bone. In this study, we found that focal radiation from frequent scans of the right tibiae in 1-month-old rats by micro-computed tomography severely decreased trabecular bone mass and deteriorated bone structure. Interestingly, PTH daily injections remarkably improved trabecular bone in the radiated tibiae with increases in trabecular number, thickness, connectivity, structure model index and stiffness, and a decrease in trabecular separation. Histomorphometric analysis revealed that radiation mainly decreased the number of osteoblasts and impaired their mineralization activity but had little effects on osteoclasts. PTH reversed these adverse effects and greatly increased bone formation to a similar level in both radiated and non-radiated bones. Furthermore, PTH protects bone marrow mesenchymal stem cells from radiation-induced damage, including a decrease in number and an increase in adipogenic differentiation. While radiation generated the same amount of free radicals in the bone marrow of vehicle-treated and PTH-treated animals, the percentage of apoptotic bone marrow cells was significantly attenuated in the PTH group. Taken together, our data demonstrate a radioprotective effect of PTH on bone structure and bone marrow and shed new light on a possible clinical application of anabolic treatment in radiotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.