Observational studyJournal of pediatric urology2013
Prevalence and risk factors for renal scars in children with febrile UTI and/or VUR: a cross-sectional observational study of 565 consecutive patients.
Observational study in Journal of pediatric urology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Evidence-based clinical practice guideline for management of urinary tract infection and primary vesicoureteric reflux.Pediatric nephrology (Berlin, Germany) · 2024Guideline
- To screen or not to screen for vesicoureteral reflux in children with ureteropelvic junction obstruction: a systematic review.European journal of pediatrics · 2017Pooled it
- Efficacy of antibiotic prophylaxis in children with vesicoureteral reflux: systematic review and meta-analysis.The Journal of urology · 2015Pooled it
- Dexamethasone to prevent kidney scarring in acute pyelonephritis: a randomized clinical trial.Pediatric nephrology (Berlin, Germany) · 2022Trial
- Patterns of damage observed on dimercaptosuccinic acid kidney scans and future risk of urinary tract infections or reduced kidney function.Pediatric nephrology (Berlin, Germany) · 2025Article
- What paediatricians need to know about modern urologic management of vesicoureteral reflux.Frontiers in pediatrics · 2025Review
- Genetic determinants of renal scarring in children with febrile UTI.Pediatric nephrology (Berlin, Germany) · 2024Article
- Long-term consequences of urinary tract infection in childhood: an electronic population-based cohort study in Welsh primary and secondary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2024Article
- Review
- Risk Factors for the Development of Febrile Recurrences in Children with a History of Urinary Tract Infection.The Journal of pediatrics · 2022Article
- Is Vesicostomy Still a Contemporary Method of Managing Posterior Urethral Valves?Children (Basel, Switzerland) · 2022Article
- Contemporary Management of Urinary Tract Infections in Children.Current treatment options in pediatrics · 2022Review
- The Spectrum of Parenchymal Changes in Kidneys Affected by Intrarenal Reflux, Diagnosed by Contrast-Enhanced Voiding Urosonography and DMSA Scan.Frontiers in pediatrics · 2022Article
- Types of Parenchymal Changes Diagnosed on DMSA Scans of Kidneys Affected by Different Grades of Vesicoureteral Reflux.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Primary Bilateral High-Grade Vesicoureteral Reflux in Children: Management Perspective.Cureus · 2020Article
- Guidelines for the medical management of pediatric vesicoureteral reflux.International journal of urology : official journal of the Japanese Urological Association · 2020Article
- Effectiveness of the smoothing filter in pediatricRadiological physics and technology · 2020Article
- Primary vesicoureteral reflux; what have we learnt from the recently published randomized, controlled trials?Pediatric nephrology (Berlin, Germany) · 2019Review
- Renal scarring following urinary tract infections in children.Sudanese journal of paediatrics · 2019Article
- Delayed diagnosis of primary vesicoureteral reflux in children with recurrent urinary tract infections: Diagnostic approach and renal outcomes.Turkish journal of urology · 2018Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo determine prevalence and risk factors for renal scar in children referred for urologic assessment of febrile UTI and/or VUR.
methodsPre-determined risk factors for renal scar were prospectively recorded in consecutive patients referred for UTI/VUR. Age, gender, VUR grade, and reported number of febrile and non-febrile UTIs were analyzed with logistic regression to determine risk for focal cortical defects on non-acute DMSA.
resultsOf 565 consecutive children, 24 (4%) had congenital renal dysplasia and 84 (15.5%) had focal defect(s). VUR, especially grades IV-V, recurrent febrile UTI, and older age increased risk. For any age child with the same number of UTIs, VUR increased odds of renal defect 5.4-fold (OR = 5.4, 95% CI = 2.7-10.6, AUC = 0.759).
conclusionsFocal DMSA defects were present in 15.5% of 565 consecutive children referred for febrile UTI and/or VUR; 4% had presumed congenital reflux nephropathy without cortical defect. All VUR grades increased risk for these defects, as did recurrent febrile UTIs and older age. However, 43% with grades IV-V VUR and 76% with recurrent UTI had normal DMSA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.