ArticleThe Kaohsiung journal of medical sciences2013
Postconditioning attenuates acute intestinal ischemia-reperfusion injury.
Article in The Kaohsiung journal of medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Extracellular matrix gene set and microRNA network in intestinal ischemia-reperfusion injury: Insights from RNA sequencing for diagnosis and therapy.World journal of gastrointestinal surgery · 2025Review
- Melatonin, programmed death ligand-1, programmed death ligand-1, and cancer: imagine beyond the future?Revista da Associacao Medica Brasileira (1992) · 2025Article
- Evaluating the safety and feasibility of remote ischemic conditioning for slowing cognitive decline in mild Alzheimer's dementia.Frontiers in neurology · 2025Article
- Effects of local and remote ischemic postconditioning methods on ischemiareperfusion injury in a young animal model of acute mesenteric ischemia.Acta cirurgica brasileira · 2023Article
- First management of percutaneous dilatational tracheostomy in severe acute respiratory syndrome coronavirus 2 akin to the vital head and neck region and thyroid gland bed: trust, but be careful whom (you trust)?Revista da Associacao Medica Brasileira (1992) · 2023Article
- Clinical Insights on Pre- and Novel Postconditioning in Equine Jejunal Ischemia.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2021Article
- Ischaemic postconditioning reduces apoptosis in experimental jejunal ischaemia in horses.BMC veterinary research · 2021Article
- Connection of reactive oxygen species as an essential actor for the mechanism of phenomena; ischemic preconditioning and postconditioning: Come to age or ripening?Northern clinics of Istanbul · 2021Review
- Interpretations on Preconditioning with Lidocaine and Xylazine in Experimental Equine Jejunal Ischaemia.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2020Article
- Ameliorative potential of conditioning on ischemia-reperfusion injury in diabetes.Conditioning medicine · 2018Article
- Ischemic Postconditioning Protects Against Intestinal Ischemia/Reperfusion Injury via the HIF-1α/miR-21 Axis.Scientific reports · 2017Article
- Very short cycles of postconditioning have no protective effect against reperfusion injury. Experimental study in rats.Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia CardiovascularArticle
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to test the hypothesis that postconditioning (POC) would reduce the detrimental effects of the acute intestinal ischemia-reperfusion (I/R) compared to those of the abrupt onset of reperfusion. POC has a protective effect on intestinal I/R injury by inhibiting events in the early minutes of reperfusion in rats. Twenty-four Wistar-Albino rats were subjected to the occlusion of superior mesenteric artery for 30 minutes, then reperfused for 120 minutes, and randomized to the four different modalities of POC: (1) control (no intervention); (2) POC-3 (three cycles of 10 seconds of reperfusion-reocclusion, 1 minute total intervention); (3) POC-6 (six cycles of 10 seconds of reperfusion-reocclusion, 2 minutes total intervention); and (4) sham operation (laparotomy only). The arterial blood samples [0.3 mL total creatine kinase (CK) and 0.6 mL malondialdehyde (MDA)] and the intestinal mucosal MDA were collected from each after reperfusion. POC, especially POC-6, was effective in attenuating postischemic pathology by decreasing the intestinal tissue MDA levels, serum total CK activity, inflammation, and total histopathological injury scores. POC exerted a protective effect on the intestinal mucosa by reducing the mesenteric oxidant generation, lipid peroxidation, and neutrophil accumulation. The six-cycle algorithm demonstrated the best protection.
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