ArticleAutonomic neuroscience : basic & clinical2013
Highlights in basic autonomic neurosciences: central adenosine A1 receptor - the key to a hypometabolic state and therapeutic hypothermia?
Article in Autonomic neuroscience : basic & clinical, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- The poikilothermic hypothesis of sepsis.Critical care (London, England) · 2026Review
- In a model of SAH-induced neurogenic fever, BAT thermogenesis is mediated by erythrocytes and blocked by agonism of adenosine A1 receptors.Scientific reports · 2021Article
- Median preoptic area neurons are required for the cooling and febrile activations of brown adipose tissue thermogenesis in rat.Scientific reports · 2020Article
- Central adenosine ABritish journal of pharmacology · 2018Article
- Thermoregulatory inversion: a novel thermoregulatory paradigm.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Hibernation, Hypothermia and a Possible Therapeutic "Shifted Homeostasis" Induced by Central Activation of A1 Adenosine Receptor (A1AR).Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology · 2016Review
- The physiology of artificial hibernation.Journal of clinical and translational research · 2015Article
- Pharmacologically induced hypothermia attenuates traumatic brain injury in neonatal rats.Experimental neurology · 2015Article
- Severe hemorrhage attenuates cardiopulmonary chemoreflex control of regional sympathetic outputs via NTS adenosine receptors.American journal of physiology. Heart and circulatory physiology · 2014Article
- Autonomic regulation of brown adipose tissue thermogenesis in health and disease: potential clinical applications for altering BAT thermogenesis.Frontiers in neuroscience · 2014Review
- Therapeutic hypothermia and targeted temperature management for traumatic brain injury: Experimental and clinical experience.Brain circulationReview
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Authors and funding
3 authors.
Funding
Abstract
The positive outcome that hypothermia contributes to brain and cardiac protection following ischemia has stimulated research in the development of pharmacological approaches to induce a hypothermic/hypometabolic state. Here we review three papers to highlight the role of the adenosine 1 receptor (A1AR) as a potential mediator and physiological regulator of a hypothermic state in both hibernating and non-hibernating mammals. We would like to emphasize the importance of comparative studies between hibernating and non-hibernating species that could lead to important discoveries on the mechanisms inducing hibernation and how they might be translated to induce a clinically useful hypothermic state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.