ArticleActa psychiatrica Scandinavica2014
General medical burden in bipolar disorder: findings from the LiTMUS comparative effectiveness trial.
Article in Acta psychiatrica Scandinavica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder.Bipolar disorders · 2018Guideline
- Challenges in the development of treatment guidelines for bipolar disorder.Frontiers in psychiatry · 2025Article
- Obsessive-Compulsive Disorder as an Epiphenomenon of Comorbid Bipolar Disorder? An Updated Systematic Review.Journal of clinical medicine · 2024Review
- Controversies regarding lithium-associated weight gain: case-control study of real-world drug safety data.International journal of bipolar disorders · 2023Article
- Exposure to psychotropic medications and mortality in schizophrenia: a 5-year national cohort study.Psychological medicine · 2023Article
- Demographic and clinical characteristics of lithium-treated older adults with bipolar disorder.Acta psychiatrica Scandinavica · 2022Article
- The Use of Repetitive Transcranial Magnetic Stimulations for the Treatment of Bipolar Disorder: A Scoping Review.Behavioral sciences (Basel, Switzerland) · 2022Article
- Bipolar symptoms, somatic burden, and functioning in older-age bipolar disorder: Analyses from the Global Aging & Geriatric Experiments in Bipolar Disorder Database project.Bipolar disorders · 2022Article
- Obesity and metabolic comorbidity in bipolar disorder: do patients on lithium comprise a subgroup? A naturalistic study.BMC psychiatry · 2021Article
- Medical Comorbidities in 181 Patients With Bipolar DisorderFrontiers in psychiatry · 2021Article
- A Web-Based Adaptation of the Quality of Life in Bipolar Disorder Questionnaire: Psychometric Evaluation Study.JMIR mental health · 2020Article
- Clinical applications of transcranial magnetic stimulation in bipolar disorder.Brain and behavior · 2019Review
- Impaired Glucose Metabolism in Bipolar Patients: The Role of Psychiatrists in Its Detection and Management.International journal of environmental research and public health · 2019Article
- Bipolar Disorder and Obesity: Contributing Factors, Impact on Clinical Course, and the Role of Bariatric Surgery.Current obesity reports · 2018Review
- Dietary influences on cognition.Physiology & behavior · 2018Article
- Cardiometabolic comorbidities, readmission, and costs in schizophrenia and bipolar disorder: a real-world analysis.Annals of general psychiatry · 2017Article
- Associations Between Gender and Obesity Among Adults with Mental Illnesses in a Community Health Screening Study.Community mental health journal · 2016Article
- Obesity, but not metabolic syndrome, negatively affects outcome in bipolar disorder.Acta psychiatrica Scandinavica · 2016Article
- Patient perceptions of physical health and bipolar symptoms: The intersection of mental and physical health.Journal of affective disorders · 2016Article
- Development of a bipolar disorder biobank: differential phenotyping for subsequent biomarker analyses.International journal of bipolar disorders · 2015Article
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15 authors.
Funding
Abstract
objectiveThis study examined general medical illnesses and their association with clinical features of bipolar disorder.
methodData were cross-sectional and derived from the Lithium Treatment - Moderate Dose Use Study (LiTMUS), which randomized symptomatic adults (n = 264 with available medical comorbidity scores) with bipolar disorder to moderate doses of lithium plus optimized treatment (OPT) or to OPT alone. Clinically significant high and low medical comorbidity burden were defined as a Cumulative Illness Rating Scale (CIRS) score ≥4 and <4 respectively.
resultsThe baseline prevalence of significant medical comorbidity was 53% (n = 139). Patients with high medical burden were more likely to present in a major depressive episode (P = .04), meet criteria for obsessive-compulsive disorder (P = .02), and experience a greater number of lifetime mood episodes (P = 0.02). They were also more likely to be prescribed a greater number of psychotropic medications (P = .002). Sixty-nine per cent of the sample was overweight or obese as defined by body mass index (BMI), with African Americans representing the racial group with the highest proportion of stage II obesity (BMI ≥35; 31%, n = 14).
conclusionThe burden of comorbid medical illnesses was high in this generalizable sample of treatment-seeking patients and appears associated with worsened course of illness and psychotropic medication patterns.
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