ArticleChemical research in toxicology2013
New GABA/glutamate receptor target for [³H]isoxazoline insecticide.
Article in Chemical research in toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 88 citations in OpenAlex.
- A randomized, controlled field study to assess the efficacy and safety of lotilaner (Credelio™) in controlling fleas in client-owned cats in Europe.Parasites & vectors · 2018Trial
- A randomised, blinded, controlled field study to assess the efficacy and safety of lotilaner tablets (Credelio™) in controlling fleas in client-owned dogs in European countries.Parasites & vectors · 2017Trial
- Safety evaluation of lotilaner in dogs after oral administration as flavoured chewable tablets (Credelio™).Parasites & vectors · 2017Trial
- Laboratory evaluation of the speed of kill of lotilaner (Credelio™) against Ixodes ricinus ticks on dogs.Parasites & vectors · 2017Trial
- Efficacy of fluralaner solution administered to egg layer chickens through drinking water for control of northern fowl mite (Ornithonyssus sylviarum).Parasites & vectors · 2026Article
- Discovery of a Novel Class of Acylthiourea-Containing Isoxazoline Insecticides againstMolecules (Basel, Switzerland) · 2023Article
- Survey of canine use and safety of isoxazoline parasiticides.Veterinary medicine and science · 2020Article
- Review on Structures of Pesticide Targets.International journal of molecular sciences · 2020Review
- Laboratory studies evaluating the efficacy of a novel orally administered combination product containing sarolaner, moxidectin and pyrantel (Simparica Trio™) for the treatment and control of flea infestations on dogs.Parasites & vectors · 2020Article
- Evaluation of the speed of kill of a novel orally administered combination product containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against induced infestations of Ixodes scapularis on dogs.Parasites & vectors · 2020Article
- Efficacy of lotilaner (Credelio™) against the adult cat flea, Ctenocephalides felis and flea eggs following oral administration to dogs.Parasites & vectors · 2020Article
- Enantioselective 5-Molecules (Basel, Switzerland) · 2019Article
- Suspected neurological toxicity after oral application of fluralaner (Bravecto®) in a Kooikerhondje dog.BMC veterinary research · 2019Article
- Efficacy of oral fluralaner for the treatment of canine generalized demodicosis: a molecular-level confirmation.Parasites & vectors · 2019Article
- The fungal alkaloid Okaramine-B activates an L-glutamate-gated chloride channel from Ixodes scapularis, a tick vector of Lyme disease.International journal for parasitology. Drugs and drug resistance · 2018Article
- Repurposing isoxazoline veterinary drugs for control of vector-borne human diseases.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Laboratory evaluation of the efficacy and speed of kill of lotilaner (CredelioParasites & vectors · 2018Article
- Safety of lotilaner flavoured chewable tablets (CredelioParasites & vectors · 2018Article
- Efficacy and safety assessment of a water-soluble formulation of fluralaner for treatment of natural Ornithonyssus sylviarum infestations in laying hens.Parasites & vectors · 2018Article
- The novel isoxazoline ectoparasiticide lotilaner (Credelio™): a non-competitive antagonist specific to invertebrates γ-aminobutyric acid-gated chloride channels (GABACls).Parasites & vectors · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The highly effective and selective isoxazoline insecticide A1443 is known to potently displace [(3)H]ethynylbicycloorthobenzoate ([(3)H]EBOB) binding to house fly head membranes with an IC50 of 0.2 nM in a manner characteristic of GABA-gated chloride channel antagonists. To further define its mode of action, we prepared phenyl-labeled [(3)H]A1443 as described with a specific activity of 14 Ci/mmol. This new radioligand with an apparent IC50 of about 0.4 nM is poorly displaced by most insecticides acting at the [(3)H]EBOB site. Interestingly, the isoxazoline binding site is directly coupled to the avermectin GABA/glutamate chloride channel activator site. These findings revive interest in the insect GABA/glutamate receptor as an insecticide target.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.