ArticleBioscience reports2013
Knockdown of cathepsin D in zebrafish fertilized eggs determines congenital myopathy.
Article in Bioscience reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Circulatory cathepsin K as biomarkers in older adults with sarcopenia: a case-control study.Frontiers in medicine · 2025Article
- Article
- The Function and the Affecting Factors of the Zebrafish Gut Microbiota.Frontiers in microbiology · 2022Review
- Lysosomal Function Impacts the Skeletal Muscle Extracellular Matrix.Journal of developmental biology · 2021Article
- Dynamic status of lysosomal cathepsin in bovine oocytes and preimplantation embryos.The Journal of reproduction and development · 2020Article
- Modeling Lysosomal Storage Diseases in the Zebrafish.Frontiers in molecular biosciences · 2020Review
- Contractile activity attenuates autophagy suppression and reverses mitochondrial defects in skeletal muscle cells.Autophagy · 2018Article
- Cathepsin B & D and the Survival of Early Embryos in Red Spotted Grouper,Development & reproduction · 2017Article
- Kinesin-1 promotes chondrocyte maintenance during skeletal morphogenesis.PLoS genetics · 2017Article
- Lowering Endogenous Cathepsin D Abundance Results in Reactive Oxygen Species Accumulation and Cell Senescence.Molecular & cellular proteomics : MCP · 2017Article
- "Muscling" Throughout Life: Integrating Studies of Muscle Development, Homeostasis, and Disease in Zebrafish.Current topics in developmental biology · 2017Review
- Cathepsin D deficiency causes juvenile-onset ataxia and distinctive muscle pathology.Neurology · 2014Article
- Modelling inborn errors of metabolism in zebrafish.Journal of inherited metabolic disease · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CD (cathepsin D) is a ubiquitous lysosomal hydrolase involved in a variety of pathophysiological functions, including protein turnover, activation of pro-hormones, cell death and embryo development. CD-mediated proteolysis plays a pivotal role in tissue and organ homoeostasis. Altered expression and compartmentalization of CD have been observed in diseased muscle fibres. Whether CD is actively involved in muscle development, homoeostasis and dystrophy remains to be demonstrated. Zebrafish (Danio rerio) is emerging as a valuable 'in vivo' vertebrate model for muscular degeneration and congenital myopathies. In this work, we report on the perturbance of the somitic musculature development in zebrafish larvae caused by MPO (morpholino)-mediated silencing of CD in oocytes at the time of fertilization. Restoring CD expression, using an MPO-non-matching mutated mRNA, partially rescued the normal phenotype, confirming the indispensable role of CD in the correct development and integrity of the somitic musculature. This is the first report showing a congenital myopathy caused by CD deficiency in a vertebrate experimental animal model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.