Evidence map›Paper›PMID 23464518›Full record

ReviewFuture medicinal chemistry2013

Potential of targeting TGF-β for organ transplant patients.

Makio Iwashima, Robert Love

Abstract readReview
In one paragraph

Review in Future medicinal chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Mesenchymal stem cells prolong the survival of orthotopic liver transplants by regulating the expression of TGF-β1.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018
    Article
  5. Human Endothelial Cells Modulate CD4Frontiers in immunology · 2018
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Makio IwashimaDepartment of Microbiology & Immunology, Stritch School of Medicine, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60153, USA. miwashima@lumc.edu
Robert Love
Loyola University Chicago · USMedical College of Wisconsin · US

Funding

Monocyte Regulation of Infant Immune ResponsesR01AI100129 · NIAID · LOYOLA UNIVERSITY CHICAGO · PI IWASHIMA, MAKIO, KNIGHT, KATHERINE L. · 2012 to 2016
$2.2M
Immunomodulatory properties of umbilical cord bloodR21AI100565 · NIAID · LOYOLA UNIVERSITY CHICAGO · PI IWASHIMA, MAKIO · 2013 to 2014
$398k
NIAID NIH HHS R01 AI100129NIAID NIH HHS R21 AI100565
6 · The paper itself

Abstract

TGF-β was originally considered as an immunoregulatory cytokine, but accumulating data demonstrate that it also plays a critical role in development of effector immunity. Since TGF- β has a potent ability to alter immune responses, modulation of the TGF-β pathway for treatment of transplantation patients could be effective if carried out in a target selective manner. This review will focus on the role of TGF-β in T cell differentiation and discuss the prospect of TGF-β as the therapeutic target of lung transplantation acceptance.

Indexed as

AnimalsApoptosisCD28 AntigensCell DifferentiationCell SurvivalHumansLungLung TransplantationReceptors, CytokineSignal TransductionT-LymphocytesTransforming Growth Factor betaTumor Suppressor Protein p53CD28 AntigensReceptors, CytokineTransforming Growth Factor betaTumor Suppressor Protein p53

Identifiers

PMID23464518
PMCPMC4429753
OpenAlexW2013693982

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.