ArticlePlant physiology2013
Thylakoid terminal oxidases are essential for the cyanobacterium Synechocystis sp. PCC 6803 to survive rapidly changing light intensities.
Article in Plant physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 121 citations in OpenAlex.
- Electron transport reactions of cyanobacterial photosynthesis and state-of-the-art in vivo measurement techniques.Plant physiology · 2026Review
- Compensatory respiration supports survival during extended heat stress inScience advances · 2026Article
- Improving tolerance to fluctuating light through adaptive laboratory evolution in the cyanobacterium Synechocystis.Nature communications · 2026Article
- From pond to platform: howJournal of bacteriology · 2026Review
- Living Photoanodes for Solar-Driven Water Oxidation.Chemical reviews · 2026Review
- Regulation of mixotrophy inMicrobiology (Reading, England) · 2026Article
- Estimating the redox state of the plastoquinone pool in algae and cyanobacteria via OJIP fluorescence: perspectives and limitations.Photosynthesis research · 2026Article
- Plastoquinone redox status influences carboxysome integrity via a RpaA- and reactive oxygen species-dependent regulatory network.The Plant journal : for cell and molecular biology · 2025Article
- Dissecting Bioelectrical Networks in Photosynthetic Membranes with Electrochemistry.Journal of the American Chemical Society · 2025Article
- Light-induced increase in the steady-state chlorophyll fluorescence in cyanobacteria reflects induction of energy dissipation complementary to orange carotenoid protein-dependent thermal dissipation.Photosynthesis research · 2025Article
- The Impact of Redox Mediators on the Electrogenic and Physiological Properties of Synechocystis sp. PCC 6803 in a Biophotovoltaic System.ChemSusChem · 2025Article
- Outlook on Synthetic Biology-Driven Hydrogen Production: Lessons from Algal Photosynthesis Applied to Cyanobacteria.Energy & fuels : an American Chemical Society journal · 2025Review
- Understanding the electron pathway fluidity of Synechocystis in biophotovoltaics.The Plant journal : for cell and molecular biology · 2025Article
- Molecular dynamics of photosynthetic electron flow in a biophotovoltaic system.Environmental science and ecotechnology · 2025Article
- Biomedical engineering utilizing living photosynthetic cyanobacteria and microalgae: Current status and future prospects.Materials today. Bio · 2024Review
- Exploring Sustainable Agriculture with Nitrogen-Fixing Cyanobacteria and Nanotechnology.Molecules (Basel, Switzerland) · 2024Review
- Dynamic Changes in the Thylakoid Proteome of Cyanobacteria during Light-Regulated Thylakoid Membrane Development.Plants (Basel, Switzerland) · 2023Article
- Differential global distribution of marine picocyanobacteria gene clusters reveals distinct niche-related adaptive strategies.The ISME journal · 2023Article
- Article
- Life in biophotovoltaics systems.Frontiers in plant science · 2023Review
1 more citing papers are in PubMed but not listed here.
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8 authors at 1 institution in 1 country.
Funding
Abstract
Cyanobacteria perform photosynthesis and respiration in the thylakoid membrane, suggesting that the two processes are interlinked. However, the role of the respiratory electron transfer chain under natural environmental conditions has not been established. Through targeted gene disruption, mutants of Synechocystis sp. PCC 6803 were generated that lacked combinations of the three terminal oxidases: the thylakoid membrane-localized cytochrome c oxidase (COX) and quinol oxidase (Cyd) and the cytoplasmic membrane-localized alternative respiratory terminal oxidase. All strains demonstrated similar growth under continuous moderate or high light or 12-h moderate-light/dark square-wave cycles. However, under 12-h high-light/dark square-wave cycles, the COX/Cyd mutant displayed impaired growth and was completely photobleached after approximately 2 d. In contrast, use of sinusoidal light/dark cycles to simulate natural diurnal conditions resulted in little photobleaching, although growth was slower. Under high-light/dark square-wave cycles, the COX/Cyd mutant suffered a significant loss of photosynthetic efficiency during dark periods, a greater level of oxidative stress, and reduced glycogen degradation compared with the wild type. The mutant was susceptible to photoinhibition under pulsing but not constant light. These findings confirm a role for thylakoid-localized terminal oxidases in efficient dark respiration, reduction of oxidative stress, and accommodation of sudden light changes, demonstrating the strong selective pressure to maintain linked photosynthetic and respiratory electron chains within the thylakoid membrane. To our knowledge, this study is the first to report a phenotypic difference in growth between terminal oxidase mutants and wild-type cells and highlights the need to examine mutant phenotypes under a range of conditions.
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