ArticleThe Plant cell2013
Empty pericarp5 encodes a pentatricopeptide repeat protein that is required for mitochondrial RNA editing and seed development in maize.
Article in The Plant cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
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102 citing papers in PubMed.
- Pentatricopeptide repeat proteins in crops: Advances in functional mechanisms and breeding applications.Journal of integrative plant biology · 2026Review
- Assembly and characterization of the first complete mitochondrial genome of Epimedium sagittatum (Sieb. et Zucc.) Maxim (Berberidaceae):an invaluable traditional Chinese medicine.BMC plant biology · 2026Article
- Assembly and comparative analysis of the complete mitochondrial genome of hexaploid oat (Avena sativa).BMC plant biology · 2026Article
- Assembly and comparative analysis of the initial complete mitochondrial genome of Verbascum thapsus (Scrophulariaceae): a medicinally and ecologically significant species.BMC plant biology · 2026Article
- Genetic Basis Analysis for Candidate QTLs and Functional Genes Controlling Four-Seeded Pods at Lower-Node in Soybean (Plants (Basel, Switzerland) · 2026Article
- Decades' progress and prospects on maize functional genomics and molecular breeding.Science China. Life sciences · 2025Review
- Exploring the role of BpPIN3 in hormonal regulation and branching morphogenesis of Betula pendula.BMC plant biology · 2025Article
- Combination of QTL mapping and GWAS for fine mapping and gene mining of drought tolerance and seed yield components in faba bean (Vicia faba L.).BMC plant biology · 2025Article
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- Seeing the unseen in characterizing RNA editome during rice endosperm development.Communications biology · 2024Article
- Mutations in nuclear genes encoding mitochondrial ribosome proteins restore pollen fertility in S male-sterile maize.G3 (Bethesda, Md.) · 2024Article
- Prognostic analysis and risk assessment based on RNA editing in hepatocellular carcinoma.Journal of applied genetics · 2024Article
- Combined BSA-Seq and RNA-Seq to Identify Potential Genes Regulating Fruit Size in Bottle Gourd (Plants (Basel, Switzerland) · 2024Article
- Multiple factors interact in editing of PPR-E+-targeted sites in maize mitochondria and plastids.Plant communications · 2024Article
- The complete mitochondrial genome ofFrontiers in plant science · 2024Article
- Genome-wide association study for yield-related traits in faba bean (Frontiers in plant science · 2024Article
- GWAS and Meta-QTL Analysis of Yield-Related Ear Traits in Maize.Plants (Basel, Switzerland) · 2023Article
- Assembly and comparative analysis of the complete mitochondrial genome of Viburnum chinshanense.BMC plant biology · 2023Article
- The emerging role of epitranscriptome in shaping stress responses in plants.Plant cell reports · 2023Review
42 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
In flowering plants, RNA editing is a posttranscriptional mechanism that converts specific cytidines to uridines in both mitochondrial and plastidial transcripts, altering the information encoded by these genes. Here, we report the molecular characterization of the empty pericarp5 (emp5) mutants in maize (Zea mays). Null mutation of Emp5 results in abortion of embryo and endosperm development at early stages. Emp5 encodes a mitochondrion-targeted DYW subgroup pentatricopeptide repeat (PPR) protein. Analysis of the mitochondrial transcripts revealed that loss of the EMP5 function abolishes the C-to-U editing of ribosomal protein L16 at the rpl16-458 site (100% edited in the wild type), decreases the editing at nine sites in NADH dehydrogenase9 (nad9), cytochrome c oxidase3 (cox3), and ribosomal protein S12 (rps12), and surprisingly increases the editing at five sites of ATP synthase F0 subunit a (atp6), apocytochrome b (cob), nad1, and rpl16. Mutant EMP5-4 lacking the E+ and DYW domains still retains the substrate specificity and editing function, only at reduced efficiency. This suggests that the E+ and DYW domains of EMP5 are not essential to the EMP5 editing function but are necessary for efficiency. Analysis of the ortholog in rice (Oryza sativa) indicates that rice EMP5 has a conserved function in C-to-U editing of the rice mitochondrial rpl16-458 site. EMP5 knockdown expression in transgenics resulted in slow growth and defective seeds. These results demonstrate that Emp5 encodes a PPR-DYW protein that is required for the editing of multiple transcripts in mitochondria, and the editing events, particularly the C-to-U editing at the rpl16-458 site, are critical to the mitochondrial functions and, hence, to seed development in maize.
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