ReviewWiley interdisciplinary reviews. Systems biology and medicine
Toward the virtual stomach: progress in multiscale modeling of gastric electrophysiology and motility.
Review in Wiley interdisciplinary reviews. Systems biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- [A New Paradigm in Diagnosing Functional Gastroduodenal Disorders: High-Resolution Electrogastrography].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2024Review
- Computational models of autonomic regulation in gastric motility: Progress, challenges, and future directions.Frontiers in neuroscience · 2023Review
- Organisation of the musculature of the rat stomach.Journal of anatomy · 2022Article
- Current applications of mathematical models of the interstitial cells of Cajal in the gastrointestinal tract.WIREs mechanisms of disease · 2021Review
- Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches.Frontiers in neuroscience · 2021Review
- The influence of interstitial cells of Cajal loss and aging on slow wave conduction velocity in the human stomach.Physiological reports · 2021Article
- Multi-scale models of lung fibrosis.Matrix biology : journal of the International Society for Matrix Biology · 2020Review
- Polygonally Meshed Dipole Model Simulation of the Electrical Field Produced by the Stomach and Intestines.Computational and mathematical methods in medicine · 2020Article
- Progress in Mathematical Modeling of Gastrointestinal Slow Wave Abnormalities.Frontiers in physiology · 2017Review
- Functional physiology of the human terminal antrum defined by high-resolution electrical mapping and computational modeling.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Original Research: Combined model of bladder detrusor smooth muscle and interstitial cells.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- A Multiphase Flow in the Antroduodenal Portion of the Gastrointestinal Tract: A Mathematical Model.Computational and mathematical methods in medicine · 2016Article
- A theoretical study of the initiation, maintenance and termination of gastric slow wave re-entry.Mathematical medicine and biology : a journal of the IMA · 2015Article
- A Multiscale Tridomain Model for Simulating Bioelectric Gastric Pacing.IEEE transactions on bio-medical engineering · 2015Article
- The impact of surgical excisions on human gastric slow wave conduction, defined by high-resolution electrical mapping and in silico modeling.Neurogastroenterology and motility · 2015Article
- Slow wave conduction patterns in the stomach: from Waller's foundations to current challenges.Acta physiologica (Oxford, England) · 2015Review
- Automated classification and identification of slow wave propagation patterns in gastric dysrhythmia.Annals of biomedical engineering · 2014Article
- A theoretical analysis of the electrogastrogram (EGG).Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2014Article
- Mapping and modeling gastrointestinal bioelectricity: from engineering bench to bedside.Physiology (Bethesda, Md.) · 2013Review
- The virtual intestine: in silico modeling of small intestinal electrophysiology and motility and the applications.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Experimental progress in investigating normal and disordered gastric motility is increasingly being complimented by sophisticated multiscale modeling studies. Mathematical modeling has become a valuable tool in this effort, as there is an ever-increasing need to gain an integrative and quantitative understanding of how physiological mechanisms achieve coordinated functions across multiple biophysical scales. These interdisciplinary efforts have been particularly notable in the area of gastric electrophysiology, where they are beginning to yield a comprehensive and integrated in silico organ modeling framework, or 'virtual stomach'. At the cellular level, a number of biophysically based mathematical cell models have been developed, and these are now being applied in areas including investigations of gastric electrical pacemaker mechanisms, smooth muscle electrophysiology, and electromechanical coupling. At the tissue level, micro-structural models are being creatively developed and employed to investigate clinically significant questions, such as the functional effects of ICC degradation on gastrointestinal (GI) electrical activation. At the organ level, high-resolution electrical mapping and modeling studies are combined to provide improved insights into normal and dysrhythmic gastric electrical activation. These efforts are also enabling detailed forward and inverse modeling studies at the 'whole body' level, with implications for diagnostic techniques for gastric dysrhythmias. These recent advances, together with several others highlighted in this review, collectively demonstrate a powerful trend toward applying mathematical models to effectively investigate structure-function relationships and overcome multiscale challenges in basic and clinical GI research.
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Registered trials
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