Evidence map›Paper›PMID 23463657›Full record

ReviewThe Journal of clinical endocrinology and metabolism2013

Challenges to the measurement of estradiol: an endocrine society position statement.

William Rosner, Susan E Hankinson, Patrick M Sluss, Hubert W Vesper, Margaret E Wierman

Open access · bronzeAbstract readConsensus StatementEvaluation StudyReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of clinical endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
170citing papers in PubMed, 11 pooled it
20.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

170 citing papers in PubMed, 11 syntheses or guidelines pooled it, 387 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Guideline
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  9. Measuring Estrogen Exposure and Metabolism: Workshop Recommendations on Clinical Issues.The Journal of clinical endocrinology and metabolism · 2015
    Guideline
  10. Pooled it
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  12. Trial
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  19. Quantifying the Role of Circulating Unconjugated Estradiol in Mediating the Body Mass Index-Breast Cancer Association.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016
    Trial
  20. Article

110 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

William RosnerDepartment of Medicine, St. Luke's-Roosevelt Hospital Center, New York, NY 10019, USA. wr7@columbia.edu
Susan E Hankinson
Patrick M Sluss
Hubert W Vesper
Margaret E Wierman
Brigham and Women's Hospital · USCenters for Disease Control and Prevention · USColumbia University · USHarvard University · USUniversity of Colorado Denver · US

Funding

BIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3M
NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA49449NCI NIH HHS R01 CA6762
6 · The paper itself

Abstract

objectiveThe objective of the study was to evaluate the current state of clinical assays for estradiol in the context of their applications.

participantsThe participants were appointed by the Council of The Endocrine Society and charged with attaining the objective using published data and expert opinion. EVIDENCE: Data were gathered from published sources via online databases (principally PubMed, Ovid MEDLINE, Google Scholar), and the clinical and laboratory experience of the participants. CONSENSUS PROCESS: The statement was an effort of the committee and was reviewed by each member. The Clinical Affairs Committee, the Council of The Endocrine Society, and JCEM reviewers reviewed the manuscript and made recommendations.

conclusionsThe measurement of estradiol in biological fluids is important in human biology from cradle to grave. In addition to its centrality in sexual development, it has significant effects on skin, blood vessels, bone, muscle, coagulation, hepatic cells, adipose tissue, the kidney, the gastrointestinal tract, brain, lung, and pancreas. Alterations in its plasma concentration have been implicated in coronary artery disease, stroke, and breast cancer. Although modern immunoassays and liquid chromatography/tandem mass spectrometry-based methods for estradiol are reasonably well suited to the diagnosis and management of infertility (nonetheless, imprecision and method-to-method differences remain problematic), the very low concentrations that appear to be crucial in nonreproductive tissues are a separate and more difficult issue. Such levels of estradiol are too low to be routinely measured accurately or precisely, and further evolution of analytical methods and the way in which estradiol is standardized is needed.

Indexed as

Diagnostic Techniques, EndocrineSocieties, MedicalDiagnostic ErrorsEndocrinologyEstradiolHumansPractice Guidelines as TopicProfessional PracticeResearch DesignEstradiol

Identifiers

PMID23463657
PMCPMC3615207
OpenAlexW1987499470

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.