Evidence map›Paper›PMID 23463651›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2013

Nine months of combined training improves ex vivo skeletal muscle metabolism in individuals with type 2 diabetes.

Lauren M Sparks, Neil M Johannsen, Timothy S Church, Conrad P Earnest, Esther Moonen-Kornips, Cedric Moro, Matthijs K C Hesselink, Steven R Smith, Patrick Schrauwen

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03563456 (Development of Structured Exercise Program Based on Patient Condition for Type 2 Diabetes Mellitus Management), which is not on this map. Cited by 68 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 10 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03563456 nacompletednot on this mapstarted 2017, after this paper: background citation

Development of Structured Exercise Program Based on Patient Condition for Type 2 Diabetes Mellitus Management

TypeinterventionalSponsorIndonesia UniversityRan2017 to 2018Enrolled42ConditionsType 2 Diabetes Mellitus, High-Intensity Interval Training, Resistance Training, Oxidative StressArmsstructured combined exercise, cardiorespiratory exercise
3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 10 syntheses or guidelines pooled it, 119 citations in OpenAlex.

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  10. Exercise training modalities in patients with type 2 diabetes mellitus: a systematic review and network meta-analysis.The international journal of behavioral nutrition and physical activity · 2018
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Lauren M SparksTranslational Research Institute for Metabolism and Diabetes, Orlando, FL 32804, USA. Lauren.Sparks@flhosp.org
Neil M Johannsen
Timothy S Church
Conrad P Earnest
Esther Moonen-Kornips
Cedric Moro
Matthijs K C Hesselink
Steven R Smith
Patrick Schrauwen
Pennington Biomedical Research Center · USMaastricht University · NLTranslational Research Institute for Metabolism and Diabetes · USUniversity of Bath · GB

Funding

Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2005 to 2026
$26.5M
NIDDK NIH HHS 2P30DK072476NIDDK NIH HHS P30 DK072476
6 · The paper itself

Abstract

contextType 2 diabetes (T2D) has features of disordered lipid and glucose metabolism, due in part to reduced mitochondrial content.

objectiveOur objective was to investigate effects of different types of exercise on mitochondrial content and substrate oxidation in individuals with T2D (ancillary study of the randomized controlled trial Health Benefits of Aerobic and Resistance Training in Individuals with Type 2 Diabetes, HART-D).

interventionT2D individuals were randomized to aerobic training (AT, n = 12), resistance training (RT, n = 18), combination training (ATRT, n = 12), or nonexercise control (n = 10). Blood draws, peak oxygen consumption tests, dual-energy x-ray absorptiometry scans and muscle biopsies of vastus lateralis were performed before and after 9 months. Ex vivo substrate oxidations ((14)CO2), mitochondrial content, and enzyme activities were measured. Glycated hemoglobin A1c and free fatty acids were also determined.

resultsMitochondrial content increased after RT and ATRT. Octanoate oxidation increased after AT and ATRT, whereas palmitate, pyruvate, and acetate oxidations increased in all exercise groups. Exercise-induced responses in mitochondrial DNA were associated with improvements in peak oxygen consumption, β-hydroxyacyl-coenzyme A dehydrogenase activity, and palmitate oxidation.

conclusionsNine months of AT and RT significantly improved most aspects of skeletal muscle mitochondrial content and substrate oxidation, whereas the combination improved all aspects. These exercise responses were associated with clinical improvements, indicating that long-term training, especially combination, is an effective lifestyle therapy for individuals with T2D by way of improving muscle substrate metabolism.

Indexed as

AgedBody CompositionCombined Modality TherapyDiabetes Mellitus, Type 2ExerciseFemaleHumansLipid MetabolismMaleMiddle AgedMitochondria, MuscleMuscle, SkeletalPhysical Education and TrainingResistance TrainingTime Factors

Identifiers

PMID23463651
PMCPMC3615199
OpenAlexW2134085809

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.