ReviewJournal of reconstructive microsurgery2013
Perioperative interventions to reduce chronic postsurgical pain.
Review in Journal of reconstructive microsurgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02437188 (Preventing Persistent Post-Surgical Pain and Opioid Use In At-Risk Veterans), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preventing Persistent Post-Surgical Pain and Opioid Use In At-Risk Veterans: Effect of ACT
Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
- The effect of preoperative dexamethasone on pain 1 year after lumbar disc surgery: a follow-up study.BMC anesthesiology · 2016Trial
- Factors in Surgical Placement and System Design to Reduce Pocket Awareness and Optimize the User Experience of Spinal Cord Stimulators - A Comprehensive Review.Journal of pain research · 2025Review
- Pudendal Nerve Neurolysis in Patients Afflicted With Pudendal Nerve Entrapment: A Systematic Review of Surgical Techniques and Their Efficacy.International neurourology journal · 2024Article
- Management of Postoperative Pain in Patients Following Spine Surgery: A Narrative Review.International journal of general medicine · 2022Review
- Evaluating the Efficacy of Two Regional Pain Management Modalities in Autologous Breast Reconstruction.Plastic and reconstructive surgery. Global open · 2022Article
- Diagnosis, Treatment, and Management of Painful Scar: A Narrative Review.Journal of pain research · 2022Review
- Post-Mastectomy Pain: An Updated Overview on Risk Factors, Predictors, and Markers.Life (Basel, Switzerland) · 2021Review
- Treatment Strategies for Generator Pocket Pain.Pain medicine (Malden, Mass.) · 2021Article
- Techniques and strategies for regional anesthesia in acute burn care-a narrative review.Burns & trauma · 2021Review
- AAAPT Diagnostic Criteria for Acute Low Back Pain with and Without Lower Extremity Pain.Pain medicine (Malden, Mass.) · 2020Review
- The effect of transversus abdominis plane block on the chronic pain after colorectal surgery: a retrospective cohort study.BMC anesthesiology · 2020Article
- Prevalence and associated predictors for patients developing chronic neuropathic pain following burns.Burns & trauma · 2020Article
- Going through laparoscopic liver resection in patients with colorectal liver metastases-A qualitative study.Nursing open · 2019Article
- Transabdominal laparoscopic retroperitoneal neurectomy for chronic pain after inguinal hernia repair and appendicectomy -a matched-pair study.BMC surgery · 2017Article
- Prospective study of neuropathic pain after definitive surgery for extremity osteosarcoma in a pediatric population.Pediatric blood & cancer · 2017Article
- Future Directions for Pain Management: Lessons from the Institute of Medicine Pain Report and the National Pain Strategy.Hand clinics · 2016Review
- A Multicenter Evaluation of the Impact of Sex on Abdominal and Fracture Pain Care.Medical care · 2015Article
- Acute Pain Medicine in the United States: A Status Report.Pain medicine (Malden, Mass.) · 2015Article
- Clonidine inhibits anti-non-Gal IgM xenoantibody elicited in multiple pig-to-primate models.XenotransplantationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Approximately 10% of patients following a variety of surgeries develop chronic postsurgical pain. Reducing chronic postoperative pain is especially important to reconstructive surgeons because common operations such as breast and limb reconstruction have even higher risk for developing chronic postsurgical pain. Animal studies of posttraumatic nerve injury pain demonstrate that there is a critical time frame before and immediately after nerve injury in which specific interventions can reduce the incidence and intensity of chronic neuropathic pain behaviors-so called "preventative analgesia." In animal models, perineural local anesthetic, systemic intravenous local anesthetic, perineural clonidine, systemic gabapentin, systemic tricyclic antidepressants, and minocycline have each been shown to reduce pain behaviors days to weeks after treatment. The translation of this work to humans also suggests that brief perioperative interventions may protect patients from developing new chronic postsurgical pain. Recent clinical trial data show that there is an opportunity during the perioperative period to dramatically reduce the incidence and severity of chronic postsurgical pain. The surgeon, working with the anesthesiologist, has the ability to modify both early and chronic postoperative pain by implementing an evidence-based preventative analgesia plan.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.