Evidence map›Paper›PMID 23463311›Full record

ReviewNature structural & molecular biology2013

Determinants of nucleosome positioning.

Kevin Struhl, Eran Segal

Abstract readReview
In one paragraph

Review in Nature structural & molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 387 papers.

0numbers the graph read from it
0cells of the map it votes in
387citing papers in PubMed
30.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

387 citing papers in PubMed, 700 citations in OpenAlex.

  1. Satellite DNAs in Drosophila koepferae (repleta group) reveal patterns of origin, chromosomal organization, transcription, and turnover in the buzzatii cluster.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026
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327 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Kevin StruhlDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA. kevin@hms.harvard.edu
Eran Segal
Harvard University · USWeizmann Institute of Science · IL

Funding

MOLECULAR MECHANISMS OF YEAST TRANSCRIPTIONAL INITIATIONR01GM030186 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI STRUHL, KEVIN · 1985 to 2018
$13.6M
Genome-wide analysis of regulated chromosomal domains: From mechanisms to cancerR01CA119176 · NCI · WEIZMANN INSTITUTE OF SCIENCE · PI REGEV, AVIV, SEGAL, ERAN · 2006 to 2015
$3.7M
MECHANISMS OF YEAST TRANSCRIPTIONAL INITITATIONR37GM030186 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI STRUHL, KEVIN · 1993 to 2002
$2.1M
NCI NIH HHS R01 CA119176NIGMS NIH HHS GM 30186NIGMS NIH HHS R01 GM030186NIGMS NIH HHS R37 GM030186
6 · The paper itself

Abstract

Nucleosome positioning is critical for gene expression and most DNA-related processes. Here we review the dominant patterns of nucleosome positioning that have been observed and summarize the current understanding of their underlying determinants. The genome-wide pattern of nucleosome positioning is determined by the combination of DNA sequence, ATP-dependent nucleosome remodeling enzymes and transcription factors that include activators, components of the preinitiation complex and elongating RNA polymerase II. These determinants influence each other such that the resulting nucleosome positioning patterns are likely to differ among genes and among cells in a population, with consequent effects on gene expression.

Indexed as

Adenosine TriphosphateBase SequenceChromatin Assembly and DisassemblyDNA-Binding ProteinsNucleosomesPoly dA-dTRNA Polymerase IITranscription FactorsYeastsAdenosine TriphosphateDNA-Binding ProteinsNucleosomesPoly dA-dTRNA Polymerase IITranscription Factors

Identifiers

PMID23463311
PMCPMC3740156
OpenAlexW2002197756

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.