Evidence map›Paper›PMID 23463310›Full record

ReviewNature structural & molecular biology2013

Regulation of nucleosome dynamics by histone modifications.

Gabriel E Zentner, Steven Henikoff

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature structural & molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 419 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
419citing papers in PubMed, 2 pooled it
52.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

419 citing papers in PubMed, 2 syntheses or guidelines pooled it, 910 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Epigenetic regulation of kidney development.Nature reviews. Nephrology · 2026
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  14. Cellular sensor DAP5 decodesFrontiers in immunology · 2026
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Synergistic roles of NFATc1 and c-Jun in immunomodulation.Biochemistry and biophysics reports · 2025
    Review
  20. Review

359 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Gabriel E ZentnerFred Hutchinson Cancer Research Center, Basic Sciences Division, Seattle, Washington, USA.
Steven Henikoff
Fred Hutch Cancer Center · US

Funding

Trans-NetworkU54CA143862 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI MELDRUM, DEIRDRE R. · 2009 to 2013
$8.4M
Chromosome Metabolism and Cancer Training GrantT32CA009657 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI EISENMAN, ROBERT NEIL · 1991 to 2020
$7.6M
Epigenomic profiling of histone turnover kinetics in mammalian cellsR01ES020116 · NIEHS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HENIKOFF, STEVEN · 2010 to 2014
$2.4M
Genome-wide profiling of histone variants in Drosophila and CaenorhabditisU01HG004274 · NHGRI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HENIKOFF, STEVEN · 2007 to 2011
$2.1M
Howard Hughes Medical InstituteNCI NIH HHS T32 CA009657NCI NIH HHS U54 CA143862NHGRI NIH HHS 5U01 HG004274NIEHS NIH HHS R01 ES020116
6 · The paper itself

Abstract

Chromatin is a dynamic structure that must respond to myriad stimuli to regulate access to DNA, and chemical modification of histones is a major means by which the cell modulates nucleosome mobility and turnover. Histone modifications are linked to essentially every cellular process requiring DNA access, including transcription, replication and repair. Here we consider properties of the major types of histone modification in the context of their associated biological processes to view them in light of the cellular mechanisms that regulate nucleosome dynamics.

Indexed as

AcetylationAcylationAdenosine DiphosphateChromatinDNADNA ReplicationGene Expression RegulationGlycosylationHistonesLysineMethylationNucleosomesAdenosine DiphosphateChromatinDNAHistonesLysineNucleosomes

Identifiers

PMID23463310
OpenAlexW2034340491

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.