ReviewCellular and molecular life sciences : CMLS2013
Deciphering microRNA code in pain and inflammation: lessons from bladder pain syndrome.
Review in Cellular and molecular life sciences : CMLS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Mir-29 repression in bladder outlet obstruction contributes to matrix remodeling and altered stiffness.PloS one · 2013Trial
- Biomarkers in the Light of the Etiopathology of IC/BPS.Diagnostics (Basel, Switzerland) · 2021Review
- miR-98-5p plays a critical role in depression and antidepressant effect of ketamine.Translational psychiatry · 2021Article
- Cyclin-dependent kinase 1 shows to be a potential genetic target for chemical cystitis.Immunity, inflammation and disease · 2021Article
- A Systematic Review of Therapeutic Approaches Used in Experimental Models of Interstitial Cystitis/Bladder Pain Syndrome.Biomedicines · 2021Review
- Urinary miRNA profiles discriminate between obstruction-induced bladder dysfunction and healthy controls.Scientific reports · 2021Article
- MicroRNA-495 alleviates ulcerative interstitial cystitis via inactivating the JAK-STAT signaling pathway by inhibiting JAK3.International urogynecology journal · 2021Article
- Mechanism of miR-320 in Regulating Biological Characteristics of Ischemic Cerebral Neuron by Mediating Nox2/ROS Pathway.Journal of molecular neuroscience : MN · 2020Article
- Epigenetic Mechanisms in Irritable Bowel Syndrome.Frontiers in psychiatry · 2020Review
- Improved isolation strategies to increase the yield and purity of human urinary exosomes for biomarker discovery.Scientific reports · 2018Article
- Functional Association between Regulatory RNAs and the Annexins.International journal of molecular sciences · 2018Review
- Do MicroRNAs Modulate Visceral Pain?BioMed research international · 2018Review
- Concordant miRNA and mRNA expression profiles in humans and mice with bladder outlet obstruction.American journal of clinical and experimental urology · 2018Article
- Correlation between polymorphisms in microRNA-regulated genes and cervical cancer susceptibility in a Xinjiang Uygur population.Oncotarget · 2017Article
- Characterization of miRNA-regulated networks, hubs of signaling, and biomarkers in obstruction-induced bladder dysfunction.JCI insight · 2017Article
- Bladder overactivity involves overexpression of MicroRNA 132 and nerve growth factor.Life sciences · 2016Article
- Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform.Journal of visualized experiments : JoVE · 2016Article
- Circulating microRNA Signatures in Rodent Models of Pain.Molecular neurobiology · 2016Article
- Irritable bowel syndrome.Nature reviews. Disease primers · 2016Review
- MicroRNA-Based Biomarkers in Pain.Advances in pharmacology (San Diego, Calif.) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs), a novel class of molecules regulating gene expression, have been hailed as modulators of many biological processes and disease states. Recent studies demonstrated an important role of miRNAs in the processes of inflammation and cancer, however, there are little data implicating miRNAs in peripheral pain. Bladder pain syndrome/interstitial cystitis (BPS/IC) is a clinical syndrome of pelvic pain and urinary urgency/frequency in the absence of a specific cause. BPS is a chronic inflammatory condition that might share some of the pathogenetic mechanisms with its common co-morbidities inflammatory bowel disease (IBD), asthma and autoimmune diseases. Using miRNA profiling in BPS and the information about validated miRNA targets, we delineated the signaling pathways activated in this and other inflammatory pain disorders. This review projects the miRNA profiling and functional data originating from the research in bladder cancer and immune-mediated diseases on the BPS-specific miRNAs with the aim to gain new insight into the pathogenesis of this enigmatic disorder, and highlighting the common regulatory mechanisms of pain and inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.