ArticleInternational urology and nephrology2013
Glomerular filtration rate in prospective living kidney donors.
Article in International urology and nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Pooled it
- Prevalence of chronic kidney diseases and its determinants among Iranian adults: results of the first phase of Shahedieh cohort study.BMC nephrology · 2022Article
- Glomerular filtration rate: new age- and gender- specific reference ranges and thresholds for living kidney donation.BMC nephrology · 2018Article
- Age-dependent reference intervals for estimated and measured glomerular filtration rate.Clinical kidney journal · 2017Article
- An Age-Calibrated Definition of Chronic Kidney Disease: Rationale and Benefits.The Clinical biochemist. Reviews · 2016Article
- HPLC estimation of iothalamate to measure glomerular filtration rate in humans.Chemistry Central journal · 2016Article
- Lifetime Risk of CKD: What Does It Really Mean?Clinical journal of the American Society of Nephrology : CJASN · 2015Article
- Changes in glomerular filtration rate after donation in living kidney donors: a single-center cohort study.International urology and nephrology · 2015Article
- Comparison of estimated GFR and measured GFR in prospective living kidney donors.International urology and nephrology · 2015Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMeasurements of glomerular filtration rate (GFR) are frequently interpreted assuming a linear variation with age. Nonlinear relationships may give a better representation of the changes associated with normal ageing.
methodsThis was a retrospective study of 904 subjects (468 women, 436 men; age range 18-84 years) undergoing assessment as prospective living kidney donors. GFR was evaluated from (51)Cr-EDTA plasma clearance using blood samples taken at 2, 3 and 4 h. The slope-intercept GFR was corrected for body surface area (BSA) using the Haycock formula and for the fast exponential using the Brochner-Mortensen equation. The relationship between age, gender and GFR was examined using best-fit curve analysis. Nonlinear relationships with age were explored using fractional polynomials.
resultsThere was no gender difference in BSA-corrected GFR over five decades of age (P = 0.40). However, female donors with a body mass index >30 kg/m(2) had a statistically significantly lower GFR than nonobese women (P < 0.01). The best-fit relationship between age and GFR was nonlinear and described using a fractional polynomial model of degree 1 (GFR = 103.9-0.0061 × Age(2) mL/min/1.73 m(2)) with a root mean standard error of 12.9 mL/min/1.73 m(2). The residual variance for this model was significantly smaller than for the best-fit linear model (P = 0.006).
conclusionsGFR measurements in prospective living kidney donors are best corrected for age using a nonlinear relationship.
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