ArticleParasitology research2013
Some characteristics of IL-5-producing T cells in mouse liver induced by Schistosoma japonicum infection.
Article in Parasitology research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- The Cytokine Profile in Different Stages of Schistosomiasis Japonica.Pathogens (Basel, Switzerland) · 2023Article
- Differential expression of T helper cytokines in the liver during early pregnancy in sheep.Animal reproduction · 2019Article
- TLR7 Modulated T Cell Response in the Mesenteric Lymph Node ofJournal of immunology research · 2019Article
- Differential Influence on Regulatory B Cells by TJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- Characteristics of Schistosoma japonicum infection induced IFN-γ and IL-4 co-expressing plasticity Th cells.Immunology · 2016Article
- The characteristics of NK cells in Schistosoma japonicum-infected mouse spleens.Parasitology research · 2015Article
- Abnormal liver function in different patients with Schistosoma japonicum.Parasitology research · 2015Article
- Characteristics of IL-17 induction by Schistosoma japonicum infection in C57BL/6 mouse liver.Immunology · 2013Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Schistosome infection could cause significant liver damage in animal; Th2 cells play an important role in the progress of this disease. In our study, C57BL/6 mice were infected by Schistosoma japonicum and lymphocytes were isolated from the liver to detect some characteristics of interleukin-5 (IL-5)-producing T cells by different methods. The results revealed that S. japonicum infection could induce a large amount of IL-5 in mouse liver T cells by the means of fluorescent bead immunoassay and RT-PCR. Although, mouse liver contained many T cell subsets, such as Th cells, Tc cells, NKT cells, and γδ T cells. Fluorescence activated cell sorting results indicated that Th cells were the main source of IL-5 in the T cell population after phorbol 12-myristate 13-acetate and ionomycin stimulation. Moreover, the percentage of IL-5-producing Th cells continued to increase from 4 to 8 weeks after S. japonicum infection, which differed from the changes of IFN-γ(+) Th1 cells, IL-4(+) Th2 cells, and IL-17A(+) Th17 cells during S. japonicum infection. Additionally, cytokines co-expression results demonstrated that 36.2 % of IL-5(+) Th cells could express IL-4, and 10 % of it could produce IFN-γ or IL-17A. Collectively, these findings implied that IL-5-producing Th cells posses some properties which differ from other cytokines secreting Th cells.
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