ReviewTranslational psychiatry2013
A role for synaptic plasticity in the adolescent development of executive function.
Review in Translational psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 221 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
221 citing papers in PubMed, 3 syntheses or guidelines pooled it, 416 citations in OpenAlex.
- Disinhibited Eating and Executive Functioning in Children and Adolescents: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- The brain in social context: A systematic review of substance use and social processing from adolescence to young adulthood.Developmental cognitive neuroscience · 2022Pooled it
- Exploring the factors affecting the implementation of tobacco and substance use interventions within a secondary school setting: a systematic review.Implementation science : IS · 2017Pooled it
- Preliminary evidence for the phosphodiesterase type-4 inhibitor, roflumilast, in ameliorating cognitive flexibility deficits in patients with schizophrenia.Journal of psychopharmacology (Oxford, England) · 2021Trial
- Trial
- Associations of Cortical and Subcortical White Matter Morphometric Abnormalities With Clinical and Genetic Findings inNeurology. Genetics · 2026Article
- Sex differences in human deep grey matter microstructure emerge during adolescence.Developmental cognitive neuroscience · 2026Article
- Ketamine attenuates anxiety-like behavior and oxidative imbalance in the maternal immune activation model: emphasis on the cerebellum.Psychopharmacology · 2026Article
- Editorial: Mechanism-specific developmental windows of opportunity in the prevention of youth psychopathology.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Sleep and the Developing Brain: What We Know, What We Don't, and Where to Act-A Systematic Review and Evidence and Gap Map.European journal of investigation in health, psychology and education · 2026Review
- Latent representations of early brain development: A multivariate normative model of brain structure and behaviour.Developmental cognitive neuroscience · 2026Article
- Executive Functioning as a Pathway Between Social Skills and Psychopathology: The Moderating Role of Autism Diagnosis.Autism research : official journal of the International Society for Autism Research · 2026Article
- Towards a neurobiology of early intervention: the importance of critical periods for preventive psychiatry and youth mental health.Molecular psychiatry · 2026Review
- Altered intrinsic connectivity in default mode and somatomotor networks in children and adolescents with ADHD: a neuroimaging meta-analysis.European child & adolescent psychiatry · 2026Article
- Expanding the electroclinical spectrum of TANC2-related disorders: Lennox-Gastaut syndrome and related developmental epileptic phenotypes.Epilepsia open · 2026Article
- Prenatal cannabinoid exposure alters excitation-inhibition balance through glutamate and GABA receptor-mediated signaling.The Journal of biological chemistry · 2026Article
- Neurophysiological markers of GABAergic and glutamatergic function associated with childhood adversity in adolescent depression: An exploratory transcranial magnetic stimulation study.Progress in neuro-psychopharmacology & biological psychiatry · 2026Article
- Divergent transcriptomic pathways underlie sex-biased cognitive rescue by developmental GSK3B inhibition in a mouse model of 22q11.2 deletion syndrome.Translational psychiatry · 2026Article
- Urinary copper is linked to regional cortical volume reductions in adolescents with major depressive disorder.Translational psychiatry · 2026Article
- Lamellar Normative Modelling of the Hippocampus Across the Human Lifespan.bioRxiv : the preprint server for biology · 2026Article
161 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adolescent brain maturation is characterized by the emergence of executive function mediated by the prefrontal cortex, e.g., goal planning, inhibition of impulsive behavior and set shifting. Synaptic pruning of excitatory contacts is the signature morphologic event of late brain maturation during adolescence. Mounting evidence suggests that glutamate receptor-mediated synaptic plasticity, in particular long-term depression (LTD), is important for elimination of synaptic contacts in brain development. This review examines the possibility (1) that LTD mechanisms are enhanced in the prefrontal cortex during adolescence due to ongoing synaptic pruning in this late developing cortex and (2) that enhanced synaptic plasticity in the prefrontal cortex represents a key molecular substrate underlying the critical period for maturation of executive function. Molecular sites of interaction between environmental factors, such as alcohol and stress, and glutamate receptor mediated plasticity are considered. The accentuated negative impact of these factors during adolescence may be due in part to interference with LTD mechanisms that refine prefrontal cortical circuitry and when disrupted derail normal maturation of executive function. Diminished prefrontal cortical control over risk-taking behavior could further exacerbate negative outcomes associated with these behaviors, as for example addiction and depression. Greater insight into the neurobiology of the adolescent brain is needed to fully understand the molecular basis for heightened vulnerability during adolescence to the injurious effects of substance abuse and stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.