Evidence map›Paper›PMID 23462880›Full record

ReviewNeurochemical research2013

Spinal cord injury: a review of current therapy, future treatments, and basic science frontiers.

Abhay K Varma, Arabinda Das, Gerald Wallace, John Barry, Alexey A Vertegel, Swapan K Ray, Naren L Banik

Abstract readReview
In one paragraph

Review in Neurochemical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Neuroprotective therapy with granulocyte colony-stimulating factor in acute spinal cord injury: a comparison with high-dose methylprednisolone as a historical control.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2015
    Trial
  3. Article
  4. Development and Evaluation of a Persian-Language Self-Management Mobile Application for People With Spinal Cord Injury.Health expectations : an international journal of public participation in health care and health policy · 2025
    Article
  5. Experimental and therapeutic medicine · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. A Spectrofluorometric Method for Real-Time Graft Assessment and Patient Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abhay K VarmaDepartment of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA. varma@musc.edu
Arabinda Das
Gerald Wallace
John Barry
Alexey A Vertegel
Swapan K Ray
Naren L Banik

Funding

South Carolina IDeA Networks of Biomedical Research (SC INBRE V)P20GM103499 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI EDIE C GOLDSMITH · 2012 to 2026
$61.0M
Supplement for South Carolina BRIN - 1P20 RR16461P20RR016461 · NCRR · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI DEAVOR, JAMES · 2001 to 2011
$32.3M
ROLE OF PROTEINASE IN SPINAL CORD INJURYR01NS031622 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BANIK, NAREN L · 1994 to 2011
$3.4M
CALPAIN ACTIVATION OF T CELLS IN DEMYELINATING DISEASER01NS041088 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BANIK, NAREN L · 2001 to 2009
$2.9M
CALPAIN IN THE PATHOPHYSIOLOGY OF DEMYELINATING DISEASER01NS038146 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BANIK, NAREN L · 1999 to 2003
$918k
Hormonal Intervention Protects Axon-myelin to Promote Functional Recovery in SCII01BX001262 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI BANIK, NAREN L · 2013 to 2025
–
BLRD VA I01 BX001262NCRR NIH HHS P20 RR016461NIGMS NIH HHS P20 GM103499NINDS NIH HHS NS-31622NINDS NIH HHS NS-38146NINDS NIH HHS NS-41088NINDS NIH HHS R01 NS031622NINDS NIH HHS R01 NS038146NINDS NIH HHS R01 NS041088
6 · The paper itself

Abstract

The incidence of acute and chronic spinal cord injury (SCI) in the United States is more than 10,000 per year, resulting in 720 cases per million persons enduring permanent disability each year. The economic impact of SCI is estimated to be more than 4 billion dollars annually. Preclinical studies, case reports, and small clinical trials suggest that early treatment may improve neurological recovery. To date, no proven therapeutic modality exists that has demonstrated a positive effect on neurological outcome. Emerging data from recent preclinical and clinical studies offer hope for this devastating condition. This review gives an overview of current basic research and clinical studies for the treatment of SCI.

Indexed as

Spinal Cord InjuriesClinical Trials as TopicHumansUnited States

Identifiers

PMID23462880
PMCPMC4103794

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.