ArticleJournal of the Association for Research in Otolaryngology : JARO2013
Congenital and prolonged adult-onset deafness cause distinct degradations in neural ITD coding with bilateral cochlear implants.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03866850 (Degenerative Consequences of Congenital Deafness), which is not on this map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Degenerative Consequences of Congenital Deafness
Who cites it
32 citing papers in PubMed, 45 citations in OpenAlex.
- Evaluation of Possible Effects of a Potassium Channel Modulator on Temporal Processing by Cochlear Implant Listeners.Journal of the Association for Research in Otolaryngology : JARO · 2018Trial
- Effects of Neonatal Deafness on Central Tonotopic Organization in Rats: an Electrophysiological Study.Clinical and experimental otorhinolaryngology · 2026Article
- Frequency Following Responses to Electric Cochlear Stimulation in an Animal Model.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Comparing Bilateral and Single-Sided Deaf Cochlear Implant Recipients in a Novel Speech-in-Noise and Localization Task.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Article
- Dissociated Representation of Binaural Cues in Single-Sided Deafness: Implications for Cochlear Implantation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Sensitivity to Pulse Rate and Amplitude Modulation in an Animal Model of the Auditory Brainstem Implant (ABI).Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- Interaural time difference sensitivity under binaural cochlear implant stimulation persists at high pulse rates up to 900 pps.Scientific reports · 2023Article
- Article
- Temporal Pitch Sensitivity in an Animal Model: Psychophysics and Scalp Recordings : Temporal Pitch Sensitivity in Cat.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Simulation of ITD-Dependent Single-Neuron Responses Under Electrical Stimulation and with Amplitude-Modulated Acoustic Stimuli.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Sound source localization patterns and bilateral cochlear implants: Age at onset of deafness effects.PloS one · 2022Article
- Interaural Place-of-Stimulation Mismatch Estimates Using CT Scans and Binaural Perception, But Not Pitch, Are Consistent in Cochlear-Implant Users.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Cochlear Implant Research and Development in the Twenty-first Century: A Critical Update.Journal of the Association for Research in Otolaryngology : JARO · 2021Review
- Microsecond interaural time difference discrimination restored by cochlear implants after neonatal deafness.eLife · 2021Article
- Ear-Specific Hemispheric Asymmetry in Unilateral Deafness Revealed by Auditory Cortical Activity.Frontiers in neuroscience · 2021Article
- Specific loss of neural sensitivity to interaural time difference of unmodulated noise stimuli following noise-induced hearing loss.Journal of neurophysiology · 2020Article
- Evaluating the Impact of Age, Acoustic Exposure, and Electrical Stimulation on Binaural Sensitivity in Adult Bilateral Cochlear Implant Patients.Brain sciences · 2020Article
- Effect of Chronic Stimulation and Stimulus Level on Temporal Processing by Cochlear Implant Listeners.Journal of the Association for Research in Otolaryngology : JARO · 2019Article
- Neural ITD Sensitivity and Temporal Coding with Cochlear Implants in an Animal Model of Early-Onset Deafness.Journal of the Association for Research in Otolaryngology : JARO · 2019Article
- Improved Neural Coding of ITD with Bilateral Cochlear Implants by Introducing Short Inter-pulse Intervals.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Bilateral cochlear implant (CI) users perform poorly on tasks involving interaural time differences (ITD), which are critical for sound localization and speech reception in noise by normal-hearing listeners. ITD perception with bilateral CI is influenced by age at onset of deafness and duration of deafness. We previously showed that ITD coding in the auditory midbrain is degraded in congenitally deaf white cats (DWC) compared to acutely deafened cats (ADC) with normal auditory development (Hancock et al., J. Neurosci, 30:14068). To determine the relative importance of early onset of deafness and prolonged duration of deafness for abnormal ITD coding in DWC, we recorded from single units in the inferior colliculus of cats deafened as adults 6 months prior to experimentation (long-term deafened cats, LTDC) and compared neural ITD coding between the three deafness models. The incidence of ITD-sensitive neurons was similar in both groups with normal auditory development (LTDC and ADC), but significantly diminished in DWC. In contrast, both groups that experienced prolonged deafness (LTDC and DWC) had broad distributions of best ITDs around the midline, unlike the more focused distributions biased toward contralateral-leading ITDs present in both ADC and normal-hearing animals. The lack of contralateral bias in LTDC and DWC results in reduced sensitivity to changes in ITD within the natural range. The finding that early onset of deafness more severely degrades neural ITD coding than prolonged duration of deafness argues for the importance of fitting deaf children with sound processors that provide reliable ITD cues at an early age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.